Aminohex Injection

Adult dosage

As total amino acids, administer intravenously at a maximum dose of 1-1.5 g per kg of body weight per day. The infusion rate should ideally allow a concentration of about 10 g as total amino acids over 60 minutes, with a principle that the administration rate is 80-130 drops per minute. The maximum daily dose is 100 g of D-sorbitol.

Children's dosage

Pediatric dosage and infusion rates should be adjusted accordingly.

This medication must be used strictly according to a doctor's instructions. It should not be used in patients with hepatic coma or those at risk of hepatic coma. It should not be administered to patients with severe renal dysfunction or elevated blood urea nitrogen levels. Its use is not suitable for patients with nitrogen metabolism issues. It should not be given to patients with cardiac wasting (cachectic) heart failure or pulmonary edema. This medication must not be used in patients with very low or absent urine output. Caution is required for patients with abnormally high sodium and chloride levels in the blood, and it should not be given if certain ingredients are included. In patients with severe dehydration, this medication should be avoided due to its specific components. It should not be used in patients with lactic acidosis or methanol poisoning due to its included ingredients. In cases where patients have hereditary fructose intolerance, administration should be avoided if certain components are included. Care should be taken for patients with issues in cardiac electrical signal conduction or severe myasthenia gravis due to the included magnesium ions. It should be avoided in patients with a history of myocardial infarction or past myocardial infarctions. Caution is necessary for patients in a severe acidosis state or congestive heart failure. Patients with sodium retention causing edema or those with high potassium levels or difficulty in potassium elimination also require caution. Patients with diabetes insipidus or liver and kidney disorders should be carefully assessed before administration. This medication can cause skin rashes as an allergic reaction, so use should be discontinued immediately if such symptoms occur. Gastrointestinal symptoms like nausea or vomiting may arise. Cardiac symptoms may include chest discomfort, palpitations, rapid pulse, and elevated blood pressure. Administering rapidly in large quantities may induce acidosis, so caution is necessary. Rarely, symptoms such as flushing, vascular pain, chills, fever, headache, dyspnea, respiratory arrest, shock, bronchospasm, and urinary spasms may occur. If magnesium ions are contained, peripheral blood vessels may dilate. Various metabolic anomalies like metabolic acidosis, hypophosphatemia, alkalosis, elevated blood sugar, diabetes, osmotic diuresis and dehydration, rebound hypoglycemia, elevated liver enzymes, vitamin imbalances, electrolyte disturbances, and hyperammonemia in children may occur. Patients with compromised liver or kidney function may experience increased blood BUN levels. Patients with severely impaired liver function are at risk of serum amino acid imbalances, metabolic alkalosis, systemic nitrogen retention, hyperammonemia, and coma. Caution is required regarding electrolyte balance when using in high doses or with solutions containing electrolytes. In case of overdose, metabolic alkalosis may occur, so care should be taken with formulations containing acetate ions. In patients with kidney disease, lung disease, or severe heart disease, care must be taken to avoid fluid overload. For diabetic patients, it's important to check blood sugar levels frequently during administration. Caution is warranted when used with certain antibiotics, as effectiveness may decrease. When magnesium ions are included, it is not advisable to administer with calcium due to potential precipitation. Safety in pregnant women has not been established; it should only be administered carefully when the therapeutic benefit outweighs the risk. For children, the drug should be given at a lower concentration due to possible immature liver function, and blood ammonia levels must be monitored frequently. Elderly patients may have decreased physiological functions, so caution should be exercised by using slower administration rates and reduced dosages. This medication contains electrolytes, thus constant attention to electrolyte balance is necessary when administered in high doses or with saline solutions. Infusions must be administered slowly intravenously, as rapid administration may induce chills or vomiting. In colder temperatures, it is preferable to warm the drug to body temperature before use. During administration, there's a risk of infection, so careful attention should be given to sterility of fluid preparation and injection equipment. If the drug solution is not clear or is discolored, it should not be used. If crystals develop in the solution, it should be appropriately heated to dissolve, then cooled to body temperature before use.

Serious side effects

Severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor), respiratory problems (dyspnea, respiratory arrest, shock, bronchospasm, asthmatic attacks, cough with fever accompanying respiratory irregularities), severe edema or urination abnormalities (markedly reduced urine output, severe systemic swelling with elevated blood pressure)

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• tachycardia
• elevated blood pressure
• acidosis
• flushing
• vascular pain

This medication should be stored in a sealed container to prevent air or moisture ingress. It should be kept in a cool room temperature, avoiding direct sunlight, meaning neither too hot nor too cold.

Appearance

A clear solution ranging from pale yellow to yellow, filled in a colorless, transparent glass container or a polypropylene aqueous injection container.

Package unit

200mL/bottle, 250mL/bottle