Cimetidine 300mg Tablets (Cimetidine)

Key information summary

Efficacy & effects

This medication is effective for conditions such as gastric and duodenal ulcers, gastroesophageal reflux disease, recurrent ulcers, postoperative anastomotic ulcers, and Zollinger-Ellison syndrome. It also helps improve mucosal lesions, bleeding, erythema, and edema occurring during acute exacerbations of acute and chronic gastritis. This medicine protects the gastric mucosa and alleviates symptoms, helping to maintain a more comfortable state. Patients can effectively manage the symptoms of gastric disorders through this medication, which is therefore used for the treatment and symptomatic improvement of such gastrointestinal disorders.

Dosage

For cimetidine, administer 400 mg orally two times a day (morning, bedtime) or 800 mg once a day (at bedtime). Additionally, administer 300 mg orally four times a day (after meals, at bedtime). The dosage can be increased up to 400 mg orally four times a day (after meals, at bedtime) (total 1.6 g). For acute gastritis and acute exacerbations of chronic gastritis, administer 200 mg orally two times a day or 400 mg once a day.

Precautions

This medication may contain glass fragments when using glass ampoules, so it should be handled carefully, especially when administered to children or the elderly. It should not be used in patients with allergic reactions or hypersensitivity to this medication, those at risk for certain cardiac arrhythmias, and patients with genetic lactose intolerance. For patients with impaired renal or liver function, the elderly, children under 19 years of age, and patients on dialysis, dosage adjustments or alteration of administration intervals may be necessary, and it should be administered only after confirming the malignancy due to the possibility of masking symptoms of gastric cancer. Various adverse reactions such as leukopenia, liver dysfunction, renal impairment, allergic reactions, dyspepsia, neurological disorders, and skin rashes may occur during the course of treatment, so patients should consult a doctor immediately if symptoms arise. It is advisable to observe the treatment effect while administering the minimum effective dose and to switch to other therapies if there is no effect. Particularly, the elderly or those with chronic conditions may have an increased risk of pneumonia, so caution is required. Due to many potential drug interactions, dosage adjustments or cessation of concurrent medications may be necessary depending on the types of drugs being taken. Women who are pregnant or breastfeeding should make careful decisions considering the effects on the fetus or newborn when using this medication, and it is recommended to discontinue breastfeeding while using it. In cases of overdose, severe side effects such as respiratory depression may occur, so immediate emergency treatment should be sought. When used as an injection, rapid intravenous administration may cause arrhythmias or hypotension, so it should be infused slowly.

Side effects

Systemic fatigue, weakness, subcutaneous hemorrhage, mucosal hemorrhage, fever → immediate cessation of administration and treatment if blood tests are necessary Jaundice, hepatitis, elevated AST, ALT → liver abnormalities Fever, renal dysfunction (elevated BUN, creatinine) → kidney abnormalities Shock, anaphylaxis-like reactions, generalized rash, respiratory distress → severe allergic reactions Altered consciousness, seizures, agitation, psychosis, depression, excitability, hallucinations, disorientation → severe neurological symptoms.

Alternatives / Same-ingredient medications

• 

  International Cimetidine Tablet

  Same ingredient
• Tagamet Injection (Cimetidine)

  Same ingredient
• 

  Cignatin Tablet (Cimetidine)

  Same ingredient
• 

  Cimetidine Tablet (Cimetidine)

  Same ingredient

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