Bosmin Solution (Epinephrine)

Key information summary

Efficacy & effects

This medication helps relieve bronchial asthma attacks and is also used to stop bleeding occurring in localized areas such as trauma or mucous membranes of the nose, mouth, and pharynx.

Dosage

In the case of bronchial asthma, a 0.1% solution is diluted 5-10 times for inhalation. The single dose should not exceed 0.3mg. If the effect is insufficient after 2-15 minutes, it may be repeated once. In cases where continuous use is necessary, intervals of 4-6 hours should be maintained. For local bleeding, a 0.1% solution is diluted 5-10 times for direct application or spraying.

Precautions

This medication should not be used in patients with angle-closure glaucoma, as it may increase intraocular pressure and pose a risk to eye health. Patients with a history of hypersensitivity or allergy to sympathomimetic agents should use this medication with caution. Patients with heart disease, including pulmonary edema, hyperthyroidism, hypertension, heart failure, and arrhythmias, should also be administered this drug carefully. Diabetic patients should be cautious as this medication may increase blood sugar levels. In patients with atherosclerosis, vascular constriction effects may worsen vascular problems, so caution is advised. Pediatric and elderly patients may be more sensitive to this medication, so the dosage should be lower and their condition closely monitored. It contains sodium bisulfite, which may cause allergic reactions or asthma attacks, so asthmatic patients should be particularly careful. When using this medication, neurological symptoms such as headache, tremors, drowsiness, dizziness, insomnia, and sweating may occur. Gastrointestinal symptoms such as indigestion, nausea, and vomiting may also arise. Cardiac-related symptoms such as palpitations, blood pressure changes, and arrhythmias should also be monitored. Irritation in the respiratory system may cause cough or bronchospasm, so symptoms should be carefully observed. If allergic reactions such as skin rashes or hives occur, use should be immediately discontinued. Conjunctival injection or pain around the eyes may develop, so it is essential to report any abnormal symptoms. If severe systemic symptoms such as pulmonary edema occur, administration should be halted. Excessive use of this medication can lead to cardiac rhythm disturbances or the risk of cardiac arrest, so it is crucial to adhere to the prescribed dosage and administration route. If there is no effect, do not continue using it and consult a physician. In particular, specific instructions for use should be provided to children, and their condition should be closely monitored. Blood potassium levels may drop, so severe asthma patients should check with blood tests. Care should be taken when using this medication with other sympathomimetics as the risk of side effects may increase. This medication should be avoided in conjunction with certain anesthetics or some psychiatric medications, as it can cause cardiac problems. Care should also be taken when used with beta-blockers or antihyperglycemic agents due to potential interactions. When used with antidepressants, the hypertensive effect may be intensified, requiring caution. Pregnant women should avoid using this medication as it may affect the oxygen supply to the fetus. Pediatric and elderly patients are sensitive to this medication, so it should be initiated at a lower dose while closely monitoring their condition. If symptoms occur due to overdose, discontinuation usually leads to resolution of most symptoms. Selective beta-blockers may be used as an antidote but caution is warranted in patients with a history of bronchospasm. This medication should not be used as an injection and should not be applied directly to the eyes. When used by methods other than inhalation, it must be done according to the directions of a physician or pharmacist. Using cloudy medication is not safe.

Side effects

Hives, angioedema, pharyngeal edema → severe allergic reaction Pallor → severe allergic reaction Pulmonary edema → respiratory issues Bronchospasm → respiratory issues

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