Buripam Tablet 50 mg (Brivaracetam)

Adult dose

This drug is taken twice daily. The recommended initial dose is 25mg or 50mg per dose, based on the healthcare provider's assessment of potential adverse effects in relation to seizure reduction. Based on clinical response and tolerability, the dose may be increased or decreased from 50mg per day [25mg per dose, twice daily] to 200mg per day [100mg per dose, twice daily]. (Tablets) This drug is a film-coated tablet. Swallow it whole with water. It may be taken with or without food. If you miss a dose If you miss one or more doses, take one dose as soon as you remember, then take the next dose at the next scheduled morning or evening time. Discontinuation When discontinuing this drug, gradually reduce the dose by 50mg per day at 1-week intervals. After taking 50mg per day for 1 week, a dose of 20mg per day is recommended for the final week (see section ‘1. Warnings’). Elderly patients (65 years and older) No dosage adjustment is required in elderly patients. Clinical experience in elderly patients aged 65 years and older is limited. Renal impairment No dosage adjustment is required in patients with renal impairment. This drug is not recommended for patients with end-stage renal disease receiving hemodialysis. Hepatic impairment Exposure to this drug is increased in patients with hepatic impairment. The recommended initial dose for patients with hepatic impairment is 50mg per day [25mg per dose, twice daily], and the recommended maximum dose is 150mg per day [75mg per dose, twice daily].

This drug is used for the treatment of epilepsy, and it may increase the risk of suicidal thoughts or behaviors, so patients and caregivers should closely monitor for these symptoms. It can cause central nervous system side effects such as drowsiness, fatigue, dizziness, and coordination difficulties, particularly in the early stages of treatment. Suddenly discontinuing this medication may lead to more frequent seizures; therefore, it must be tapered off gradually under the guidance of a physician. If there is an allergic reaction to any ingredient in this drug or if there are any specific genetic disorders such as lactase deficiency, this medication should not be taken. Patients with poor liver function may need dosage adjustments, and caution is advised if there is an allergy to specific coloring agents. During treatment, mental health status should be regularly monitored for signs of depression, anxiety, suicidal thoughts, or psychotic symptoms, and if severe skin reactions occur, treatment should be discontinued immediately, and medical attention should be sought. Taking this medication with alcohol may worsen drowsiness or impair concentration, so it is advisable to avoid alcoholic beverages. There may be interactions with other antiepileptic medications or multiple drugs, so patients should inform their doctor or pharmacist about any other medications they are taking. The effects of this drug on the fetus during pregnancy are not well established; therefore, its use should be avoided during pregnancy, and women planning to become pregnant should consult their doctor. If breastfeeding, the potential for this drug to be excreted in breast milk needs to be carefully considered alongside the benefits and risks of taking it while nursing. The safety and efficacy in children under 16 years of age have not been established, so use in this age group is not recommended. In the initial stages of taking this medication, drowsiness or dizziness may occur, so it is safer to avoid dangerous activities such as driving or operating machinery. In cases of overdose, symptoms such as drowsiness, dizziness, anxiety, aggression, and depression may occur, and as there is no specific antidote, medical care should be sought immediately.

• suicidal ideation
• suicidal behavior
• drowsiness
• fatigue
• dizziness
• cooperative movement disorder
• influenza
• type 1 hypersensitivity
• neutropenia
• decreased appetite

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it is best to keep it at room temperature between 1 degree and 30 degrees Celsius. Storing it this way will help maintain its effectiveness and prevent degradation.

Appearance

Light orange oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle