Brivaracetam 100 mg (Brivaracetam)

Adult dose

Take this medicine twice daily. The recommended initial dose is 25mg or 50mg per dose, based on the healthcare provider’s assessment of the potential side effects in relation to seizure reduction. Based on clinical response and tolerability, the dose may be increased or decreased from 50mg per day[25mg twice daily] to 200mg per day[100mg twice daily]. This medicine is a film-coated tablet. Swallow it whole with water. It may be taken with or without food. If you miss one or more doses, take one dose as soon as you remember, and then take the next dose at the next morning or evening dose time. If you wish to stop taking this medicine, gradually reduce the dose by 50mg per day at 1-week intervals. After taking 50mg per day for 1 week, a dose of 20mg per day is recommended for the final week (see section ‘1. Warnings’). Elderly patients (65 years and older): Dose adjustment is not required for elderly patients. Clinical experience in elderly patients aged 65 years and older is limited. Dose adjustment is not required in patients with renal impairment. This medicine is not recommended for patients with end-stage renal disease who are receiving hemodialysis. Exposure to this medicine is increased in patients with hepatic impairment. The recommended initial dose for patients with hepatic impairment is 50mg per day[25mg twice daily], and the recommended maximum dose is 150mg per day[75mg twice daily].

This medication is used for the treatment of epilepsy and may cause serious psychological symptoms such as suicidal thoughts or behavior, so careful observation is required. CNS side effects such as drowsiness, fatigue, and dizziness may occur not only at the beginning of treatment but also at any time during therapy. Abruptly stopping the medication may lead to more frequent seizures, so it must be gradually reduced according to the doctor's instructions. Patients with hypersensitivity to this drug or genetic metabolic disorders such as lactose intolerance should not take it. Patients with poor liver function may need dose adjustments, so it should be administered with caution. During the use of this medication, various side effects such as infections, depression, anxiety, insomnia, skin rashes, etc. may occur. If any unusual symptoms arise, the medical staff should be notified immediately. Particularly, severe skin reactions such as Stevens-Johnson syndrome may occur, so the condition of the skin should be carefully monitored. Taking this medication with alcohol can affect psychomotor function and attention, so drinking should be avoided. There may be interactions when used in combination with other antiepileptic drugs; therefore, if you are taking any other medications, you must inform your doctor or pharmacist. The safety of this medication during pregnancy has not been sufficiently established and should only be taken when absolutely necessary. Caution is also needed while breastfeeding as the drug may be excreted in breast milk. The safety and efficacy of this medication have not been established in children under 16 years of age, so it is advisable not to use it. Drowsiness or dizziness may occur while taking this medication, so dangerous activities such as driving or operating machinery should be avoided until symptoms have completely resolved. In the event of overdose, symptoms such as drowsiness, dizziness, anxiety, and aggression may occur, and as there is no specific antidote, immediate medical treatment should be sought.

• suicidal ideation
• suicidal behavior
• drowsiness
• fatigue
• dizziness
• coordination movement disorder
• influenza
• type 1 hypersensitivity reaction
• neutropenia
• decreased appetite

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. Additionally, it is recommended to store it away from direct sunlight at a cool room temperature between 1°C and 30°C.

Appearance

Olive green oval film-coated tablet

Package unit

60 tablets/box [10 tablets/PTP x 6]