Haleem Aripiprazole Tablet 2 mg

Adult dose

Adults with schizophrenia: The recommended initial dose is 10 mg or 15 mg once daily, with or without food. For the treatment of schizophrenia, the dose of this drug may be adjusted within the range of 10-30 mg per day. The dose should not be increased before 2 weeks, which is the time required to reach steady state. Maintenance treatment of schizophrenia in adults: The efficacy of this drug as maintenance treatment for schizophrenia was demonstrated in a clinical trial evaluating relapse versus placebo at a dose of 15 mg per day in patients with schizophrenia who had been stabilized on another antipsychotic for at least 3 months. Patients should be regularly reassessed to determine the need for maintenance treatment. Switching from another antipsychotic: When switching from an existing antipsychotic to this drug, it is most appropriate to start this drug while gradually reducing the dose of the existing medication. The period of overlapping treatment with most antipsychotics should be minimized. Treatment of manic and mixed episodes associated with bipolar disorder, adults: The recommended initial dose, as monotherapy or as adjunctive therapy with lithium or valproate, is 15 mg once daily, with or without food. The dose may be increased to 30 mg per day based on clinical response. Doses exceeding 30 mg per day have not been evaluated in clinical trials. Maintenance treatment of manic and mixed episodes associated with bipolar disorder, adults: The efficacy of maintenance treatment for bipolar I disorder was demonstrated in a clinical trial in patients stabilized on this drug for at least 6 weeks (as monotherapy at 15 mg or 30 mg per day). Patients should be regularly reassessed to determine the need for maintenance treatment. Adjunctive treatment of major depressive disorder, adults: The recommended initial dose for adults taking an existing antidepressant is 2~5mg once daily, with or without food. The efficacy of this drug as adjunctive treatment for major depressive disorder has been established at doses of 2~15mg per day. The dose of this drug should be increased gradually by increments within the range of 5mg or less, at intervals of at least 1 week. Maintenance treatment as adjunctive therapy for major depressive disorder, adults: Maintenance treatment as adjunctive therapy for major depressive disorder has not been evaluated. Patients should be regularly reassessed to determine the need for maintenance treatment. CYP2D6 poor metabolizers: 1/2 of the usual dose Strong CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine) or strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin): 1/2 of the usual dose Strong CYP3A4 inducers (e.g., carbamazepine, rifampin): 2 times the usual dose over 1~2 weeks However, when aripiprazole is used as adjunctive therapy for major depressive disorder, it should be administered without dose adjustment.

Child dose

Adolescents with schizophrenia (13-17 years): The recommended dose is 10 mg per day, with or without food. Doses of 10 mg and 30 mg per day were studied in adolescent patients (13-17 years). The initial daily dose was 2 mg, increased to 5 mg after 2 days and then to 10 mg after another 2 days. Thereafter, the dose was increased in increments of 5 mg. However, a dose of 30 mg per day was not more effective than a dose of 10 mg per day. Treatment of manic and mixed episodes associated with bipolar disorder, pediatric patients (10-17 years): The recommended dose as monotherapy is 10 mg per day, with or without food. Efficacy has been demonstrated at doses of 10 mg or 30 mg per day in pediatric patients (10-17 years) with bipolar I disorder. The initial dose is 2 mg per day, increased to 5 mg after 2 days and then to 10 mg after another 2 days. Thereafter, the dose should be increased in increments of 5 mg. Irritability associated with autistic disorder, pediatric patients (6-17 years): The efficacy of this drug has been demonstrated at doses of 5 mg to 15 mg per day in pediatric patients (6-17 years) with autistic disorder. The recommended initial dose is 1mg or 2mg per day, and the dose should be increased to 5 mg per day and, if necessary, then to 10 mg or 15 mg per day. Dose adjustments up to 5 mg per day should be made gradually at intervals of at least 1 week. The dose of this drug should be individualized according to tolerability and response. Tourette's disorder, pediatric patients (6-18 years): The efficacy of this drug has been demonstrated at doses of 2 mg to 20 mg per day in pediatric patients (6-18 years) with Tourette's disorder. The initial dose is 2 mg per day, gradually increased in increments of 5mg at intervals of at least 2 weeks. The dose of this drug should be individualized according to tolerability and response.

This drug may increase the risk of suicidal thoughts or behaviors in children, adolescents, and young adults with depression or psychiatric disorders. Therefore, patients and their families should carefully monitor for suicidal impulses or unusual behavioral changes during treatment with this drug. This drug may cause serious side effects known as Neuroleptic Malignant Syndrome; therefore, symptoms such as high fever, muscle rigidity, changes in mental state, or irregular pulse or blood pressure should prompt immediate medical attention. Long-term use may lead to irreversible tardive dyskinesia, so this medication should only be used at the minimum effective dose and for the shortest duration necessary, with consultation with a doctor if symptoms arise. In elderly patients with dementia, using this drug may increase the risk of strokes and mortality; thus, it is not recommended for such patients. This drug may raise blood sugar levels, so diabetic patients or those with risk factors for diabetes should ensure tight blood sugar management, and immediately inform healthcare providers if high blood sugar symptoms occur. During treatment with this drug, there is a risk of blood clots; therefore, caution is necessary and appropriate preventive measures should be taken if there are risk factors for thrombosis. Patients with allergic reactions or hypersensitivity should not take this medication, and patients with lactose intolerance should also avoid this drug. Orthostatic hypotension may occur, so if dizziness or fainting occurs, the patient should immediately inform a doctor, and caution is advised for patients at risk of cardiovascular disorders or hypotension. Patients with a history of seizures or at high risk for seizures must consult with healthcare providers before taking this medication. This drug may cause drowsiness or cognitive impairment; thus, care should be taken when driving or operating dangerous machinery. Thermoregulatory abilities may be impaired, so caution should be exercised when exposed to excessive hot environments or during strenuous exercise. Patients at risk for dysphagia or aspiration pneumonia should use this medication with extra caution. Common side effects during use may include nausea, vomiting, constipation, headache, dizziness, akathisia, anxiety, insomnia, restlessness, drowsiness, fatigue, appetite changes, weight gain, agitation, tremors, sedation, hypersalivation, blurred vision, somnolence, thirst, fever, malaise, muscle pain, joint pain, stuttering, hyperactivity, sleep disturbances, palpitations, paresthesia, hallucinations, gastrointestinal disorders, drooling, urinary disturbances, loss of appetite, polyuria, urinary retention, and polyuria. Neurological side effects such as extrapyramidal symptoms, muscle rigidity, tremor, or akathisia may also occur; patients should consult a doctor if such symptoms arise. During treatment with this drug, regular blood tests and EKG monitoring are necessary to detect any abnormalities early and manage them. If any severe or sudden onset adverse symptoms or side effects occur, immediately inform healthcare providers and seek appropriate measures.

• Suicidal thoughts
• suicidal behavior
• anxiety
• restlessness
• panic attacks
• insomnia
• irritability
• hostility
• aggression
• impulsiveness

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. Additionally, it should be stored at room temperature between 1°C and 30°C, avoiding extreme heat or cold. Proper storage will help maintain the efficacy of the medication for a longer period.

Appearance

Green rectangular tablet

Package unit

30 tablets/bottle, 100 tablets/bottle