Empagliflozin and Metformin Tablets 12.5/500 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosing for this medication is 1 tablet at a time, to be taken twice daily. The dosage is determined by considering each patient's treatment regimen, efficacy, and tolerability, without exceeding the daily maximum of 25 mg for empagliflozin and 2000 mg for metformin. - For patients who have difficulty controlling blood sugar with monotherapy of metformin or other drugs such as insulin, the recommended dosage is 5 mg of empagliflozin taken twice daily (total of 10 mg) along with the existing dose of metformin.

This medication is used to lower blood sugar, and caution is needed as it can cause rare side effects such as severe lactic acidosis. When used with other diabetes medications, there can be a risk of hypoglycemia, so monitoring blood sugar status is essential. Patients with poor kidney function, acute kidney problems, severe infections, heart failure, and certain health conditions should not use this medication. It should be temporarily discontinued before and after tests that use iodinated contrast agents, and can only be resumed once kidney function has returned to normal. Women who are pregnant or nursing are advised not to use this medication. This drug can cause fluid loss, so patients at risk of dehydration should use it cautiously, as should the elderly and patients with cardiovascular diseases. Genital and urinary tract infections may occur during use, so if symptoms arise, consult a doctor immediately. Due to a potential drop in vitamin B12 levels, regular testing may be required during long-term use. In case of overdose, serious side effects such as lactic acidosis may occur, so dosage must be strictly followed, and medical attention should be sought immediately if side effects occur. Alcohol consumption should be avoided during treatment, and caution is necessary after sudden decreases in food intake or intense exercise due to the risk of hypoglycemia. The medication should be discontinued for a period before and after surgery, and resumed only after confirming kidney function is normal. This medication is not recommended for children under 18, and in elderly patients, starting at the minimum dosage while regularly monitoring kidney function is advisable. During treatment, consult a physician regarding possible interactions with other medications.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, pain in oral/ocular mucosa, breathing difficulties or shortness of breath, asthma attacks, cough with fever and respiratory abnormalities, yellowing of skin or eyes (jaundice), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, vision abnormalities, paralysis.

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain storage temperatures between 1 to 30 degrees Celsius.

Appearance

Biconvex oval film-coated tablets with a light brownish-purple color

Package unit

60 tablets/bottle, 60 tablets/box [10 tablets/PTP x 6]