Nextrone Pre-filled Injection (Ramosetron Hydrochloride)

Adult dosage

In adults, Ramosetron Hydrochloride is administered intravenously at a dose of 0.3 mg once daily. If the effect is insufficient, the same dose may be administered additionally. However, do not exceed 0.6 mg in a single day. Adjust the dosage appropriately based on symptoms.

This medication should not be used in patients who have had an allergic reaction to this drug or any of its components. Caution should be exercised when administering this medication to patients taking other serotonergic drugs, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs). Serious allergic reactions such as shock or anaphylaxis may occur while using this drug; if symptoms appear, immediate discontinuation of administration and consultation with healthcare professionals are necessary. Seizure symptoms similar to epilepsy have been reported, so if such symptoms are suspected, they should be reported to healthcare professionals immediately. Various side effects such as headache, diarrhea, liver dysfunction, skin rash or itching may occur; any abnormal symptoms should be reported to healthcare professionals. This medication is primarily used in patients undergoing anti-cancer treatment that causes severe nausea and vomiting. Co-administration of this drug with other serotonergic medications may result in a serious condition known as serotonin syndrome, so patient status should be closely monitored in such cases. Since this drug is primarily metabolized in the liver, caution is required when taken with certain medications as blood concentrations may increase, raising the risk of side effects. Women who are pregnant or may become pregnant should carefully consider the benefits and risks of using this medication, and it is advisable to discontinue breastfeeding if nursing. The safety in children has not been sufficiently confirmed, so caution is necessary when used. Elderly patients may have decreased bodily functions; therefore, their condition should be closely monitored when administering this drug, and immediate discontinuation is required if adverse reactions occur. This drug may undergo chemical changes when mixed with certain injection solutions; therefore, it is advisable not to mix. Animal experiments have reported that this drug may affect fetal growth; attention should be paid when administering to pregnant women.

Serious side effects

Shock, symptoms similar to anaphylaxis (discomfort, chest discomfort, difficulty breathing, asthma, facial flushing, redness, itching, cyanosis, hypotension, etc.), seizure-like symptoms.

Mild side effects

Headache, feeling of heaviness in the head, diarrhea, constipation, itching, redness, rash, feeling of heat in the body, hiccups, warmth in the head, tingling of the tongue, insomnia, rashes, liver dysfunction (elevated AST, ALT, r-GTP, elevated bilirubin), elevated BUN, elevated serum creatinine.

This drug should be stored in a dark place to protect it from light exposure, and it is important to keep it in a sealed container to prevent air from entering. Additionally, it should be stored at room temperature between 1 degree and 30 degrees Celsius to maintain effectiveness.

Appearance

A colorless and transparent liquid in a single-use pre-filled syringe.

Package unit

5 pre-filled syringes/box (2 milliliters/pre-filled syringe), 6 pre-filled syringes/box (2 milliliters/pre-filled syringe)