Petra Tablet (Letrozole)

Adult dose

○ Adults and elderly patients : The recommended dose is 2.5 mg of letrozole orally once daily, regardless of meals. If a dose is missed, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and continue taking the medicine according to the regular schedule. Do not take a double dose to make up for a missed dose; do not exceed the recommended dose of 2.5 mg. In patients with metastatic disease, continue treatment until disease progression is confirmed. For adjuvant therapy and extended adjuvant therapy following adjuvant tamoxifen therapy, treatment may be given for 5 years. If cancer recurs during treatment, discontinue the medicine (for extended adjuvant therapy following adjuvant tamoxifen therapy, the optimal treatment duration associated with long-term use has not been established.). ○ Patients with hepatic impairment : Although the blood concentration of this medicine is slightly increased in patients with moderate hepatic impairment due to cirrhosis, no dose adjustment is necessary in patients with mild to moderate hepatic impairment. However, if this medicine is used in patients with severe hepatic impairment (Child-Pugh score C), continuous and careful supervision is required. ○ Patients with renal impairment : No dose adjustment is necessary in patients with renal impairment and a creatinine clearance of 10 mL/min or more.

This medication should not be used in certain patients. Women who are allergic to this medication or its components, premenopausal women, pregnant or possibly pregnant women, and breastfeeding women should not take this medication. Additionally, this medication contains lactose, so patients with lactose intolerance or certain genetic metabolic disorders should also avoid it. Patients with significantly impaired kidney function, severe liver dysfunction, a history of osteoporosis, or high fracture risk need special caution when using this medication. Patients whose menopausal status is uncertain should confirm their menopause status through hormone testing before taking this medication. Patients with allergies to the coloring agents in this medication should also use it with caution. This medication is primarily used for the treatment of breast cancer in women and works by inhibiting the production of estrogen hormones. This can lead to common side effects such as facial flushing, arthralgia, nausea, fatigue, hair loss, vaginal bleeding, loss of appetite, headache, dizziness, sleepiness, insomnia, memory impairment, sensory abnormalities, taste disturbances, cataract, eye irritation, blurred vision, palpitations, tachycardia, hypertension, cough, vomiting, indigestion, constipation, diarrhea, abdominal pain, stomatitis, dry mouth, increased liver enzymes, sweating, dry skin, rash, itching, hives, angioedema, erythema multiforme. Serious side effects, such as cardiac problems, thrombosis, liver dysfunction, and skin allergic reactions may rarely occur, and if symptoms appear, immediate consultation with medical personnel is necessary. This medication is metabolized in the liver, so interactions with other medications may occur. Particularly, concomitant use of drugs that inhibit or induce liver enzymes may alter the effects of this medication, so any other medications that are being taken must be disclosed. It may pose risks to pregnant or breastfeeding women and should never be taken, requiring adequate contraception for premenopausal women. The safety and efficacy of this medication have not been established in children under 17 years of age. Elderly patients do not require special dosage adjustments, but caution is necessary due to a higher risk of fractures. In case of overdose, there is no specific antidote, so symptomatic treatment and monitoring of the condition are important. This medication should be kept out of the reach of children and stored in its original container to prevent quality degradation and misuse.

• urinary tract infection
• tumor pain
• leukopenia
• anaphylactoid reaction
• hypercholesterolemia
• loss of appetite
• increased appetite
• depression
• anxiety
• irritability

This medication should be stored in a tightly closed container to protect it from air and moisture, and kept in a cool place below 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness over time.

Appearance

Dark yellow round film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]