Niserin 10mg Tablet (Niserogline)

Adult dose

* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally per dose, 3 times daily before meals. Adjust the dose as appropriate according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. Reduce the dose in patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL).

This medication should not be used in certain patients. For example, it should not be administered to patients with allergies to this drug or ergot alkaloids, those with acute myocardial infarction, acute bleeding, patients who are taking sympathomimetic drugs, patients with very slow heart rates, patients who have not achieved hemostasis after intracranial bleeding, and those with orthostatic dysregulation. Additionally, this drug should be used cautiously in patients with mild bradycardia or impaired kidney function. While taking this medication, gastrointestinal symptoms such as loss of appetite, diarrhea, constipation, nausea, vomiting, abdominal pain or cramps, and dry mouth may occur rarely. Liver function abnormalities may lead to increased liver enzyme levels. Cardiovascular symptoms such as dizziness, orthostatic dysregulation, hypertension, elevated uric acid levels, and hypotension may also occur rarely. In the mental and neurological systems, symptoms such as drowsiness, fatigue, headache, tinnitus, tiredness, and insomnia may appear. Allergic reactions such as rash, hives, itching, flushing, and warmth may occur rarely, so caution should be exercised. This medication can enhance the blood pressure-lowering effect when taken with other antihypertensive drugs, so frequent blood pressure monitoring is necessary. Also, because it can affect uric acid metabolism, patients with a history of hyperuricemia or gout should use it carefully. After taking this medication, caution is required when driving or operating machinery. This drug is metabolized in the liver by a specific enzyme (CYP450 2D6), so there may be interactions with other medications that utilize this enzyme. Women who are pregnant or of childbearing potential should weigh the risks and benefits carefully when taking this drug, and breastfeeding women should avoid administration or discontinue breastfeeding. Elderly patients may require caution and dose adjustments due to decreased bodily function. Safety in children has not been established, so use in pediatrics needs caution. In case of overdose, blood pressure may temporarily decrease, thus blood pressure should be measured and necessary actions taken. Finally, this medicine should be kept out of the reach of children and stored tightly closed in the original container to prevent misuse or degradation in quality.

• Loss of appetite
• diarrhea
• constipation
• nausea
• vomiting
• localized upper abdominal pain
• cramps
• dry mouth
• ALT elevation
• AST elevation

This medication may be sensitive to air and moisture, so it should be stored in a sealed container. The storage temperature should be kept between 1°C and 30°C at room temperature. Proper storage will help maintain the effectiveness of the medication for a longer time.

Appearance

White round film-coated tablet

Package unit

Tablet/Bottle - 30 tablets/bottle, Tablet/Bottle - 100 tablets/bottle