Laniglu Duo Extended-Release Tablet 2.5/1000mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication is to be taken once daily with evening meals. The dosage of metformin hydrochloride should be increased gradually and should not be chewed, split, or crushed to maintain its extended-release properties. The 5/1000 mg extended-release tablet is taken once daily, one tablet at a time. The 2.5/1000 mg extended-release tablet is taken once daily, two tablets simultaneously. 1. Currently on metformin treatment:

This medication may rarely cause serious lactic acidosis or hypoglycemia, so caution is needed. Patients with allergies to any component of this medication or those with type 1 diabetes, severe renal impairment, liver dysfunction, acute infections, or heart diseases should not use this medication. If taken with insulin or sulfonylurea medications, dosage adjustments may be necessary due to increased risk of hypoglycemia. Patients with decreased renal function should undergo regular kidney function tests, and this medication should not be taken if kidney function is severely impaired. In cases of acute renal failure or receiving iodinated contrast agents, this medication should be temporarily discontinued and resumed only after kidney function has recovered. Pregnant or nursing women are advised to avoid using this medication and should consult a physician if planning a pregnancy. This medication should be swallowed whole and not chewed, crushed, or split; there is no need to worry if the coating of the tablet is expelled unchanged. Long-term use may lead to vitamin B12 deficiency; therefore, monitoring through blood tests may be necessary. Patients taking this medication should consult a doctor immediately if sudden abdominal pain, skin rashes, or blistering skin disease symptoms occur. Elderly patients are at higher risk of decreased kidney function, so dosage adjustments and regular kidney function tests are necessary. Overdosage may cause gastrointestinal disturbances or lactic acidosis, so the dosage must be strictly followed as per the doctor's instructions. Additionally, there may be interactions when taken with other medications, so patients should inform their doctors or pharmacists of any other medications they are taking.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, abnormal breathing alongside cough + fever, yellowing of skin or eyes (jaundice), extreme drowsiness, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis

Mild side effects

Nasopharyngitis, hypersensitivity reactions, hypoglycemia, taste disorders, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, liver function abnormalities, hepatitis, itching, redness, rash, severe but non-disabling arthralgia, increased lipase, increased amylase, angioedema, vascular disorders (hypotension, flushing), chest pain, fever, fatigue, dizziness, headache, drowsiness, anxiety, insomnia, depression, vertigo, limb pain

This medication should be stored in a tightly sealed container to protect it from air and moisture, at a temperature between 1 and 30 degrees Celsius. Proper storage will maintain the medication's effectiveness and safety.

Appearance

Oval-shaped extended-release tablet, white to almost white, with A251 engraved on one side.

Package unit

28 tablets/box (7 tablets/PTP x 4), 30 tablets/bottle