Nisem Tablet 30 mg (Nisergoline)

Adult dose

* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally 2 ∼ 3 times daily before meals. Adjust the dose as appropriate according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before meals. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. For patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL), administer a reduced dose.

This medicine should not be used in certain patients. For example, individuals allergic to this medicine or ergot alkaloids should not take it. Additionally, patients who have recently suffered a heart attack or have acute bleeding should not take this medicine. Patients taking sympathomimetic drugs or those with very slow heart rates should also avoid this medicine. Patients who have not completed hemostasis following a brain hemorrhage or those with symptoms of orthostatic hypotension should avoid using this medicine. This medication should be administered cautiously to patients with mild bradycardia or impaired kidney function. Rarely, gastrointestinal issues such as appetite loss, diarrhea, constipation, nausea, vomiting, abdominal pain, and dry mouth may occur upon taking this medication. Liver function tests may show elevated values. Symptoms of cardiovascular abnormalities such as dizziness, orthostatic hypotension, blood pressure changes, and increased serum uric acid levels may also rarely occur. Neurological symptoms such as drowsiness, fatigue, headache, and insomnia may occur. There may be allergic reactions causing rashes, hives, itching, facial flushing, and heat sensations, so caution is advised. Taking this medicine with other antihypertensives may enhance the blood pressure-lowering effect, so it is important to check blood pressure frequently. It may affect uric acid metabolism; therefore, gout patients or those with hyperuricemia should exercise particular caution. After taking this medicine, one should be careful when driving or operating machinery. This medicine is metabolized in the liver through a specific enzyme (CYP450 2D6), so interactions with other medications metabolized through the same pathway may occur. Pregnant women or those who may become pregnant should use this medicine cautiously as it may affect the fetus; consultation with a doctor is necessary. If breastfeeding, it is advisable to either avoid this medication or discontinue breastfeeding since it may be secreted in breast milk. Elderly patients may have decreased bodily function, so careful use and dose adjustment are necessary. Safety in pediatric patients has not yet been established, so its use in children is not recommended. In case of overdose, blood pressure may temporarily decrease, so careful observation and necessary measures should be taken.

Loss of appetite, diarrhea, constipation, nausea, vomiting, occasional upper abdominal pain or cramps, thirst, elevated ALT, elevated AST, dizziness, orthostatic dysregulation, hypertension, elevated blood uric acid levels, blood pressure reduction, drowsiness, fatigue, headache, tinnitus, tiredness, insomnia, rash, hives, itching, flushing, heat sensation, nightmares, mood disturbances, indigestion

This medicine should be stored in a light-protected, airtight container at a temperature between 1°C and 30°C. Proper storage will help maintain the efficacy of the medication.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle