Divalproez Sodium Extended-Release Tablets 500 mg (Divalproex Sodium)

Adult dose

This drug is administered once daily in a form that must be swallowed whole without breaking or chewing the tablet. 1. Treatment of seizures - Monotherapy for complex partial seizures: The initial dose is 10-15 mg per kg of body weight per day, and the dose is increased by 5-10 mg per kg of body weight weekly until an optimal clinical response is achieved. Doses exceeding 60 mg per kg of body weight per day are not recommended. - Simple and mixed absence seizures: The initial dose is

Child dose

This drug can be administered to children aged 10 years and older. 1. Treatment of seizures - Monotherapy for complex partial seizures: The initial dose is 10-15 mg per kg of body weight per day, and the dose is increased by 5-10 mg per kg of body weight weekly until optimal clinical response is achieved.

This drug should not be administered to pregnant women except in special cases. Women of childbearing age must strictly adhere to a pregnancy prevention program, and if not, this drug should not be used. The effectiveness of this drug may be reduced when used with estrogen-containing hormonal contraceptives; therefore, the patient's condition should be carefully monitored at the initiation and termination of therapy. This drug may increase the risk of suicidal thoughts or behavior; thus, mood changes or unusual behavioral signs should be closely monitored during treatment. Because serious liver damage may occur, this drug should be used cautiously, especially in young children or patients with compromised liver function, and liver function tests should be performed regularly during the first 6 months of treatment. If symptoms of pancreatitis appear, such as abdominal pain, nausea, vomiting, or loss of appetite, medical attention should be sought immediately, and the drug should be discontinued if pancreatitis is diagnosed. Patients with urea cycle disorders must confirm the presence of such disorders before taking this drug, as hyperammonemia-related encephalopathy may occur. Elderly patients may experience more pronounced sedation or dehydration symptoms, so the dosage should be increased slowly and their condition should be closely monitored. Thrombocytopenia may occur, thus regular blood tests to check platelet levels before and during treatment are necessary, and any bleeding symptoms should be reported to medical personnel immediately. This drug should be avoided in combination with certain antibiotics (carbapenems) as it may decrease its blood concentration, leading to diminished therapeutic effect. Women of childbearing age must use an effective method of contraception during treatment and consult medical personnel immediately if pregnancy is planned or confirmed. Drowsiness or dizziness may occur during treatment; therefore, it is advisable to avoid driving or operating dangerous machinery. Regular testing of liver function, blood counts, and pancreatic function should be conducted, and if any abnormal symptoms arise, immediate consultation with a physician is recommended. Abruptly discontinuing the drug may worsen symptoms; therefore, when discontinuing, it must be tapered off according to medical personnel's instructions.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blistering, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough + fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urine

Mild side effects

• Headache
• weakness
• fever
• nausea
• vomiting
• abdominal pain
• diarrhea
• loss of appetite
• indigestion
• constipation

This drug should be stored in a tightly sealed container to prevent air or moisture from entering. The storage temperature should be maintained between 1 and 30 degrees Celsius at room temperature.

Appearance

Gray oval-shaped extended-release coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle