Jardiance Duo Tablet 12.5/1000 mg (Empagliflozin, Metformin)

Adult dose

The recommended dosage of this medication is 1 tablet, taken twice a day. Dosage should be determined considering the patient's treatment regimen, effectiveness, and tolerance, not exceeding 25 mg of empagliflozin and 2000 mg of metformin. For patients receiving metformin alone or in combination with other drugs, the recommended dosage is 5 mg of empagliflozin twice a day (total daily dose of 10 mg) along with their existing dose of metformin. For those with good tolerance requiring additional blood sugar control, the dosage of empagliflozin can be increased to 25 mg (total daily dose). For patients transitioning to this medication from a combination of empagliflozin (total daily dose of 10 mg or 25 mg) and metformin, dosing should be done based on their existing doses of empagliflozin and metformin. When used in conjunction with sulfonylureas or insulin, dosage reductions of sulfonylureas or insulin can be considered to reduce the risk of hypoglycemia (see warnings and interactions). This medication should be taken with meals to reduce gastrointestinal side effects associated with metformin. If a dose is missed, it should be taken as soon as remembered but should not be doubled. If so, the missed dose should be skipped.

This medication can cause severe lactic acidosis, which is very rare but can be fatal, so caution is advised. Symptoms of hypoglycemia may occur when used with other diabetes medications, so caution is necessary. Patients with moderate to severe renal impairment or acute kidney issues should not use this medication. Patients in serious conditions such as acute infections, heart disease, or sepsis should also avoid administration. It is not suitable for patients with type 1 diabetes or a history of ketoacidosis. Before and after tests using radiographic contrast agents, renal function should be checked, and the medication should be discontinued if necessary. Patients scheduled for surgery should stop taking this medication 48 hours prior to surgery and resume afterward. Patients with liver dysfunction, severe lung disease, excessive alcohol intake, or dehydration symptoms should also be cautious. Women who are pregnant or breastfeeding should not take this medication. Elderly patients are at higher risk of fluid loss, requiring increased caution when taking this medication and regular monitoring of renal function. This medication may cause side effects such as hypoglycemia, urinary tract infections, genital infections, and increased urination, so if symptoms appear, patients should consult healthcare professionals immediately. Regular blood tests are recommended as vitamin B12 levels may decrease. Alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid it during treatment. Patients are particularly advised to be cautious of irregular meals, excessive exercise, and taking other medications during treatment. Since there may be a possibility of drug interactions, patients should inform healthcare professionals of any other medications they are taking. This medication is not recommended for children and adolescents under 18 years old, as its safety and efficacy have not been established. In the case of overdose, patients should immediately visit a medical institution for appropriate treatment, and dialysis may be required. This medication should be stored out of reach of children and kept in its original container for safety.

Serious side effects

Hives, severe swelling (angioedema), ketoacidosis, lactic acidosis, urosepsis, pyelonephritis, perineal necrosis, severe skin adverse reactions (severe rash, blisters, skin peeling, mucosal pain in mouth/eyes), severe allergic reactions, severe edema, or urination abnormalities (significant decrease in urine volume, severe swelling throughout the body, accompanied by elevated blood pressure), difficulty breathing, asthma attacks, respiratory issues (coughing with fever), liver abnormalities (jaundice, skin

Mild side effects

• Nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation
• altered taste
• itching
• rash
• erythema

This medication should be stored in a tightly closed container to prevent contact with air or moisture. Additionally, it is best to store the medication at room temperature between 1°C and 30°C. Proper storage will help maintain the effectiveness of the medication for a longer period.

Appearance

Biconvex, oval-shaped, film-coated tablet with a dark brownish-purple color

Package unit

60 tablets/bottle [10 tablets/PTP x 6], 30 tablets/bottle, 10 tablets/box [10 tablets/PTP x 1], 60 tablets/bottle