Nesinamet Sustained Release Tablet 12.5/1000 mg (Alogliptin, Metformin Hydrochloride)

Adult dose

The 25/1000 mg sustained-release tablet is taken once a day, one tablet at a time. Patients taking either the 12.5/1000 mg or 12.5/500 mg sustained-release tablet should take two tablets at the same time once a day. 1. If currently not treated with metformin The initial dose of this medication is 25 mg of alogliptin and 1000 mg of metformin hydrochloride as the total daily dose. If the initial dose does not provide sufficient blood sugar control, the dosage of metformin can be gradually increased up to the maximum recommended daily dosage of 2000 mg.

This medication can cause severe lactic acidosis or hypoglycemia; therefore, it should not be used especially in patients with poor kidney function or heart disease. Patients with allergic reactions to alogliptin or metformin or those who have had serious skin reactions in the past should not take this medication. Patients with moderate to severe renal impairment, acute heart failure, or myocardial infarction should not take this medication, and it should be temporarily discontinued before and after undergoing examinations using iodinated contrast agents. Caution is required when using this medication in conditions such as diabetic ketoacidosis, severe infections, pre- and post-surgery, malnutrition, liver dysfunction, severe pulmonary disease, and excessive alcohol consumption. This medication can cause side effects such as gastrointestinal disturbances, headache, infections, and hypoglycemia, so it is important to closely monitor blood sugar changes due to the risk of hypoglycemia. If symptoms of liver dysfunction appear, you should consult a doctor immediately, and it is important to regularly undergo liver function tests and kidney function tests. If acute dehydration or severe vomiting, diarrhea occurs while taking this medication, you must stop taking it immediately and seek medical attention. It is safer for women who are pregnant or may become pregnant or who are breastfeeding not to take this medication. Combining with other antidiabetic agents or certain medications may increase the risk of hypoglycemia, so if there are concomitant medications, you must consult with healthcare professionals. In special circumstances such as surgery or radiological examinations, this medication should be temporarily discontinued, and it should be resumed after confirming that renal function is normal. In the elderly, kidney function decline is common, so renal function should be frequently monitored, and the dosage should be adjusted while taking this medication. In cases of overdose, special treatment may be necessary, and for metformin, dialysis may be helpful. This medication should be taken strictly according to a doctor's prescription and guidance, and if any abnormal symptoms appear, immediate consultation with healthcare professionals is required.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough+fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, vision changes, paralysis, urination

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• diarrhea
• hypertension
• headache
• back pain
• urinary tract infections
• hypoglycemia
• nausea/vomiting
• bloating

This medication should be stored in a sealed container to prevent air exposure, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. This way of storage helps maintain the medication's efficacy and prevents deterioration.

Appearance

Pale yellow oval-shaped sustained-release film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle