Empagliflozin and Metformin Hydrochloride Tablet 12.5/850 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage is 1 tablet per dose, twice a day. The dosage should not exceed 25 mg of empagliflozin and 2000 mg of metformin, and should be determined considering each patient's current treatment regimen, efficacy, and tolerance. If sufficient blood sugar control is not achieved with metformin alone or in combination with insulin or other medication, a dose of empagliflozin 5 mg, taken twice a day (total of 10 mg daily) may be added to the existing metformin dosage.

This medication can cause a rare but very serious side effect known as severe lactic acidosis, so patients at high risk for lactic acidosis should use caution. During treatment, hypoglycemia may occur if used with other diabetes medications such as insulin or sulfonylureas, thus blood sugar levels should be monitored carefully. Patients with moderate to severe renal impairment, acute kidney problems, severe infections, or cardiovascular issues should not use this medication. If undergoing surgery or tests using iodinated contrast, this medication should be discontinued for a period, and renal function should be verified as normal before resuming. This medication may cause fluid loss, so special caution is necessary for patients with dehydration symptoms or at risk for decreased fluid volume. Women who are pregnant or may become pregnant, and nursing mothers should not use this medication; especially during pregnancy, insulin therapy is recommended. Regular monitoring of liver or kidney function tests is advised during treatment to check for abnormalities. If symptoms such as fever, pain, redness, swelling in the genital or perineal area occur, immediate medical attention should be sought. This medication may reduce vitamin B12 levels, so patients on long-term treatment should periodically check their vitamin B12 levels. Alcohol can increase the risk of side effects from this medication, so excessive drinking should be avoided during treatment. Elderly patients, particularly those aged 75 and older, are at higher risk for fluid loss and should take caution, possibly requiring dose adjustments based on renal function. In the event of an overdose, immediate medical treatment is required, and if lactic acidosis is suspected, blood dialysis may be necessary. Finally, this medication should be kept out of the reach of children and safely stored in the original container.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, lactic acidosis, ketoacidosis, severe allergic reactions, severe rash with fever, blisters, skin peeling, pain in oral/mucous membranes, severe skin reactions, asthma attacks, respiratory difficulties accompanied by cough and fever, shortness of breath or breathing difficulty, liver problems (symptoms of jaundice), yellowing of skin or eyes (jaundice), extreme lethargy, severe

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly sealed container to protect it from air and moisture. A storage temperature between 1 and 30 degrees Celsius at room temperature is recommended. Proper storage helps maintain the medication's effectiveness over time.

Appearance

White, oval-shaped, double-sided convex film-coated tablet with a pink tint

Package unit

60 tablets/box [(10 tablets/PTP x 6)], 10 tablets/box [(10 tablets/PTP x 1)], 30 tablets/bottle, 60 tablets/bottle