Vildaduo M Tablets 50/500 mg (Vildagliptin, Metformin Hydrochloride)

Adult dose

The dosage of this medication should be individualized based on efficacy and tolerability, with a maximum of 100 mg of vildagliptin and 2000 mg of metformin. A dose of vildagliptin greater than 100 mg per day is not recommended. Taking the medication with food or immediately after a meal may reduce gastrointestinal side effects due to metformin. 1. For patients with no prior experience of diabetes medication treatment and insufficient glycemic control with monotherapy: The initial dose is 50/500 mg taken once daily, gradually increasing to 50/1000 mg taken twice daily, with one tablet each time. 2. For patients transitioning from combination therapy of vildagliptin and metformin: Patients switching from combination therapy of vildagliptin and metformin can start with the previous doses of vildagliptin and metformin. Studies evaluating the safety and efficacy of transitioning from other oral hypoglycemic agents to this medication have not been conducted. Any changes in the diabetes treatment regimen can affect blood sugar control, so careful monitoring is necessary. If a dose is missed, unless it is time for the next dose, take it with the next meal and do not take double the dose to compensate for the missed one. Patients with liver dysfunction: This medication is not recommended for patients with clinical or laboratory evidence of liver impairment, including those with ALT or AST levels exceeding 2.5 times the normal upper limit before administration.

This medication is used for the treatment of diabetes and contains two active ingredients. You must confirm that kidney function is normal before taking this medication, and patients with severely impaired kidney function should not take this medication. Additionally, patients whose kidney function is compromised due to severe heart failure, acute myocardial infarction, sepsis, etc., should avoid taking this medication. This medication can cause a serious side effect known as lactic acidosis, which is a condition characterized by increased blood lactate levels and acidosis. Though rare, it can be fatal, so caution is required. Particularly, if dehydration, severe diarrhea, vomiting, or fever occurs, this medication should be stopped immediately, and medical consultation should be sought. Patients with liver dysfunction should also avoid taking this medication, and regular liver function tests should be conducted during treatment. This medication can cause hypoglycemia, so extra caution is necessary in cases of irregular or insufficient food intake, vigorous exercise, or when taken with other blood sugar-lowering agents. Pregnant or nursing women should not take this medication, and its use is not recommended for children or teenagers under 18 years old. Elderly patients may have decreased kidney function, so it is important to check kidney function before use and monitor regularly. Patients scheduled for surgery should stop taking this medication 48 hours prior to surgery and should only resume after confirming that kidney function is normal post-surgery. Excessive alcohol consumption increases the risk of lactic acidosis; therefore, alcohol should be avoided during treatment with this medication. Moreover, this medication may interact with other drugs, so patients taking other medications should inform their physician or pharmacist. If abnormal symptoms occur during treatment, such as abdominal pain, shortness of breath, muscle pain, weakness, hypothermia, or changes in consciousness, immediate consultation with medical personnel is needed. This medication is not for patients with type 1 diabetes who require insulin treatment. Lastly, this medication should be stored out of reach of children, and changing the container is not safe.

Serious side effects

Hives, angioedema, hepatitis, blisters, exfoliative skin lesions, bullous pemphigoid, severe allergic reactions, severe skin adverse reactions, liver abnormalities (jaundice), lactic acidosis, acute pancreatitis, severe joint pain with complications and disabilities, bullous pemphigoid, difficulty breathing, severe edema, or urinary issues

Mild side effects

• Tremor
• headache
• dizziness
• fatigue
• nausea
• gastroesophageal reflux
• diarrhea
• bloating
• chills
• decreased blood sugar

This medication should be stored in a sealed container to prevent exposure to air or moisture and kept in a cool place below 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a longer time.

Appearance

Bright yellow oval film-coated tablets

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle