Dapagliflozin M Extended-Release Tablet 10/500 mg

Adult dose

This medication is typically administered once daily with the evening meal. The maximum dosage is 10 mg of dapagliflozin/2000 mg of extended-release metformin once daily, and 2 tablets of 5 mg/1000 mg. For those with no prior experience in diabetes medication treatment, the initial regimen is 5 mg/500 mg or 10 mg/500 mg one tablet once daily. To reduce gastrointestinal side effects of metformin, dosages are adjusted in stages.

This medication is used for treating diabetes and should not be administered to patients with reduced kidney function or certain health conditions. It may rarely cause a life-threatening metabolic complication known as lactic acidosis, so caution is required for patients with impaired kidney function or those experiencing severe infections, dehydration, etc. Also, when used in conjunction with insulin or sulfonylurea medications, the risk of hypoglycemia may increase, necessitating dosage adjustments. This medication may cause genital and urinary tract infections, and especially women or those with a history of infections should be vigilant about infection symptoms. Due to potential reduced fluid volume or symptoms of hypotension, elderly patients or those taking diuretics should regularly monitor their blood pressure and fluid status. This medication should not be used in patients with liver impairment, pregnant or nursing women, and those with lactose intolerance. It is advised to avoid alcohol while taking this medication, and if undergoing sudden surgery or contrast examinations, it should be temporarily discontinued. Blood levels of vitamin B12 may decrease, so regular blood tests are recommended for prolonged use. In case of overdose, immediate contact with a medical facility for proper treatment is essential, and while this medication has little influence on driving or machine operation, caution should be taken as dizziness may occur. Lastly, this medication should be kept out of reach of children and stored in its original container to prevent misuse or quality deterioration.

Serious side effects

Lactic acidosis, severe hypoglycemia, dehydration, hypovolemia, hypotension, diabetic ketoacidosis, urosepsis, pyelonephritis, acute kidney injury, renal dysfunction, Guillain-Barré syndrome, atrial fibrillation, acute cholecystitis, perineal necrosis, severe allergic reactions, severe skin adverse reactions, respiratory problems, liver abnormalities (jaundice), severe neurological symptoms, significant swelling or urination abnormalities.

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, reduced fluid volume, thirst, dizziness, constipation, dry mouth, low back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, elevated hematocrit, initial decrease in renal creatinine clearance, dyslipidemia, initial increase in serum creatinine, elevated blood urea, weight loss, rash, diarrhea, nausea/vomiting, reduced/deficiency of vitamin B12, Guillain-Barré syndrome, bacterial.

This medication should be stored in a tightly closed container to prevent exposure to air or moisture, ideally at room temperature between 1 degrees and 30 degrees. By storing this way, the medication's efficacy can be maintained and safely used.

Appearance

Pink, bilaterally convex, oval extended-release film-coated tablet

Package unit

30 tablets/box [(6 tablets/PTP*5)], 30 tablets/bottle, 200 tablets/bottle