Sitaplus Sustained-Release Tablet 50/500 mg (Sitagliptin, Metformin)

Adult dose

To reduce gastrointestinal adverse effects from metformin, take once daily with meals, preferably at dinner, gradually increasing the dose. To maintain sustained-release properties, do not split, crush, grind, or chew the tablet; swallow it whole. For Sitaplus sustained-release 100/1000 mg, take once daily, one tablet at a time. For this 50/500 mg sustained-release tablet or 50/1000 mg sustained-release tablet, patients should take two tablets at one time once daily.

This medication contains two active ingredients: sitagliptin and metformin. Sitagliptin can cause severe allergic reactions in some patients, which may include anaphylaxis (acute allergic shock), angioedema (swelling of the skin or mucous membranes), and severe skin conditions such as Stevens-Johnson syndrome. These hypersensitivity reactions can occur within the first three months of starting the medication, so if symptoms such as skin rash or difficulty breathing occur, you should stop taking the medication immediately and consult a doctor. Additionally, this medication can cause acute pancreatitis, a serious inflammation of the pancreas, so if symptoms such as abdominal pain, nausea, or vomiting occur while taking it, you should stop taking it immediately and inform healthcare personnel. The metformin component can cause a rare but serious condition called lactic acidosis, which is a buildup of lactic acid in the blood. This condition is particularly risky for patients with impaired kidney function, dehydration, severe infections, or heart failure. Therefore, it should not be taken in these situations. Patients with moderate to severe renal impairment, acute heart failure, acute myocardial infarction, sepsis, and those undergoing radiocontrast iodine testing should not be administered this medication. Pregnant women or those who may become pregnant and nursing mothers should also avoid using this medication. When taking this medication, it is important to be cautious due to the increased risk of hypoglycemia or lactic acidosis arising from irregular eating habits, insufficient meal sizes, strenuous exercise, or interactions with other medications. This medication should also be used cautiously in individuals with allergies to certain colorants. During use, gastrointestinal disturbances, headaches, dizziness, rashes, and other side effects may occur, so it is important to consult healthcare personnel if any unusual symptoms arise.

Serious side effects

• Hives, angioedema, anaphylaxis, and serious skin conditions like Stevens-Johnson syndrome → Severe allergic reactions
• Symptoms of acute pancreatitis → Pancreatitis
• Severe lactic acidosis
• Sudden difficulty breathing, asthma attacks
• Liver dysfunction (jaundice, yellowing of the skin or eyes)
• Severe neurological symptoms (severe headache, seizures, confusion)
• Severe swelling or urination abnormalities
• Difficulty breathing, chest tightness, paleness, cold sweat
• Severe skin reactions.

Mild side effects

• Nausea
• vomiting
• diarrhea
• dyspepsia
• abdominal pain
• decreased appetite
• headache
• dizziness
• rash
• muscle pain

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. Also, it should be kept in an environment that is neither too hot nor too cold, ideally at room temperature between 1°C and 30°C.

Appearance

Light blue, oval-shaped, biconvex sustained-release film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle