Pashiga Jeng 10mg (Dapagliflozin Propanediol Hydrate)

Adult dose

The recommended dosage for this medication is once daily 10 mg for monotherapy and additional combination therapy with insulin and other hypoglycemic agents. In the case of initial combination therapy with metformin, the initial recommended dose is either 5 mg or 10 mg once daily. The recommended dosage for patients with chronic heart failure and chronic kidney disease is 10 mg once daily. Dose adjustments may be necessary in patients with renal and hepatic impairment.

Child dose

The efficacy and safety of dapagliflozin in pediatric patients under 18 years of age have not been established, and its use is not recommended.

This medication should not be used in patients who are allergic to the active ingredient or excipients, in patients with type 1 diabetes, diabetic ketoacidosis patients, patients with lactose intolerance, or patients undergoing dialysis. Caution is required when used in patients with reduced fluid volume or impaired kidney function due to the risk of low blood pressure or kidney damage. This medication may cause side effects such as genital infections, urinary tract infections, hypoglycemia, dehydration, dizziness, constipation, dry mouth, back pain, etc. Especially, genital infections and urinary tract infections may occur more frequently in women and patients with a history of previous infections, hence prompt treatment is required when symptoms arise. In severe cases, serious infections such as perineal necrosis may occur, so immediate medical attention should be sought if pain or swelling occurs around the perineum. Additionally, this medication can cause serious metabolic disturbances known as ketoacidosis, so immediate examination should be undertaken if symptoms like nausea, vomiting, abdominal pain, or difficulty breathing develop. Elderly patients or those taking diuretics face a higher risk of decreased fluid volume and hypotension, requiring closer monitoring. Women who are pregnant or breastfeeding should avoid using this medication, and discontinuation should occur if pregnancy is confirmed. This medication may increase the risk of hypoglycemia when used with insulin or sulfonylureas, requiring possible dosage adjustments of those drugs. In case of overdose, there is no specific antidote, so appropriate treatment should be administered according to symptoms, and rapid consultation with medical personnel is important. During the use of this medication, caution should be exercised for symptoms of hypoglycemia when driving or operating machinery. Finally, the safety and efficacy of this medication in children have not been established, so it should not be used, and it should be kept out of the reach of children.

Serious side effects

Perineal necrosis (Fournier's gangrene), reduced fluid volume, diabetic ketoacidosis, acute kidney injury, renal dysfunction, severe swelling, increased blood pressure, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, chest tightness, difficulty breathing, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of the skin or eyes), profound fatigue, sudden and severe headache, thunderclap headache.

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, dizziness, constipation, back pain, dysuria, polyuria, nocturia, genital itching, increased hematocrit, elevated serum creatinine levels at the beginning of treatment, dyslipidemia, weight loss, rash, angioedema, chest pain, weakness, pain, swelling, foreign body sensation, facial swelling, facial pain, warmth, flu-like symptoms, menstrual irregularities, dermatitis

This medication should be stored in a tightly sealed container to protect it from air and moisture. Additionally, it is best stored at room temperature between 1 to 30 degrees Celsius. Caution should be taken as storing the medication in extremely hot or cold places can diminish its effectiveness.

Appearance

Yellow, biconvex, rhomboid film-coated tablets

Package unit

28 tablets/box [14 tablets/Alu-Alu*2]