Sitagliptin Metformin Extended Release Tablet 50/1000 mg

Adult dose

For the 100/1000 mg extended-release tablet, take one tablet once daily. Patients taking the 50/500 mg extended-release tablet or the 50/1000 mg extended-release tablet should take two tablets at once once daily. 1. For patients not currently treated with metformin: The initial total daily amount is 100 mg of sitagliptin and 1000 mg of metformin. If necessary, the metformin dose may be gradually increased.

This medication contains two ingredients: sitagliptin and metformin. Firstly, the sitagliptin component can cause rare but serious allergic reactions. These reactions can include hives, angioedema, anaphylaxis, or severe skin conditions with skin peeling. If any abnormal symptoms appear within three months after taking the medication, the drug should be immediately discontinued and a doctor should be consulted. Additionally, sitagliptin carries a risk of acute pancreatitis, which involves inflammation of the pancreas. If symptoms of pancreatitis such as abdominal pain or vomiting occur during treatment, the medication must be stopped immediately and medical personnel should be informed. Secondly, the metformin component can cause a rare side effect called lactic acidosis, which is a dangerous condition characterized by abnormal accumulation of lactic acid in the blood, with symptoms including muscle pain, breathing difficulties, and fatigue. Immediate treatment is necessary if these symptoms occur. This medication should not be administered to patients with moderate to severe renal impairment, acute heart failure, severe infections, dehydration, acute myocardial infarction, patients scheduled for radiographic contrast examinations, type 1 diabetes patients, or women who are pregnant or breastfeeding. Particularly, if a patient is to undergo a contrast procedure, this medication should be paused for a certain period before and after the examination to reduce kidney burden, and it should only be resumed after confirming normal kidney function. Furthermore, patients with irregular eating habits, excessive exercise, those taking certain medications, and those allergic to the ingredient Yellow No. 4 (tartrazine) should be cautious when using this medication. During treatment, abnormal symptoms such as gastrointestinal disturbances, hypoglycemia, and allergic reactions may occur, thus careful observation is necessary, and immediate consultation with medical personnel is required if any abnormal symptoms appear.

Serious side effects

• Severe hypersensitivity reactions (anaphylaxis, angioedema, Stevens-Johnson syndrome, etc.)
• Acute pancreatitis
• Lactic acidosis and hypoglycemia

Mild side effects

Gastrointestinal disturbances

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and it is important to maintain a temperature between 1 degree and 30 degrees Celsius at room temperature. Proper storage will help maintain the medication's effectiveness and prevent degradation.

Appearance

Bright green oval extended-release film-coated tablets

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle