Poglo M Sustained-Release Tablet 10/1000 mg (Dapagliflozin Propanediol Monohydrate, Metformin Hydrochloride)

Adult dose

This medication is typically administered once daily with the evening meal. The maximum dosage is once daily dapagliflozin 10 mg/sustained-release metformin 2000 mg, with 2 tablets at 5 mg/1000 mg. For those with no previous experience of diabetic medication treatment, the initial therapy should consist of one tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, doses should be titrated gradually.

This medication helps in controlling blood sugar. However, there are several important precautions to be taken when using this medication. First, this medication can rarely cause a dangerous condition called lactic acidosis. Lactic acidosis occurs when there is a build-up of lactic acid in the body, which can be life-threatening if severe, so consult a doctor immediately if symptoms appear. Additionally, when this medication is used with insulin or other diabetes medications, hypoglycemia may occur, so blood glucose levels should be closely monitored, and medication dosages adjusted if necessary. This medication should not be administered to patients with severely impaired kidney function, patients in a dehydrated state, patients with serious infections or heart issues, and those with acute myocardial infarction. Also, pregnant or breastfeeding women, as well as individuals with certain genetic disorders, should not take this medication. Before administration, fluid status and kidney function must be evaluated, and special caution is necessary for the elderly or individuals with slightly impaired kidney function. This medication can increase urination, possibly leading to decreased fluid levels or low blood pressure, so those at risk for hypotension should frequently check their blood pressure and fluid status. During treatment, genital and urinary infections may occur, and if these symptoms appear, immediate treatment is required. Furthermore, this medication can lower vitamin B12 levels, so it is advisable to check vitamin B12 status during long-term use. Alcohol consumption may increase the risk of side effects from this medication, so excessive drinking should be avoided while on this drug. If undergoing surgery or iodine contrast tests, administration should be temporarily halted, and it should be restarted only after confirming normal kidney function. In case of overdose, appropriate treatment is required, and while this medication does not significantly affect driving or machine operation abilities, dizziness may occur, so caution is advised. Finally, this medication should be kept out of reach of children and stored in its original container to maintain its quality.

Serious side effects

Lactic acidosis, severe hypoglycemia, acute kidney injury, severe edema, diabetic ketoacidosis, urosepsis, pyelonephritis, serious skin reactions (severe rash, blistering, peeling skin, pain in mucous membranes of mouth/eyes), severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness), severe neurological symptoms (sudden and severe headache, lightning headache, seizures, confusion, vision disturbances, paralysis)

Mild side effects

Hypoglycemia, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, external genital itching, genital itching, increased hematocrit, reduced early treatment renal creatinine clearance, dyslipidemia, increased serum creatinine, increased blood urea, weight loss, diarrhea, nausea/vomiting, decreased/deficiency of vitamin B12, upper abdominal pain, dyspepsia, abdominal discomfort, abdominal pain, gastric ulcer, irritable bowel syndrome, salivary gland enlargement, and tooth decay

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is advisable to keep the storage temperature between 1°C and 30°C at room temperature. This will help maintain the medication's effectiveness and safety over time.

Appearance

Yellow, double-convex oval sustained-release film-coated tablets

Package unit

Bottle packaging - 30 tablets/bottle, Bottle packaging - 100 tablets/bottle