Dapagluem Sustained Release Tablet 10/1000 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is dapagliflozin 10 mg and sustained-release metformin 2000 mg, taken as 2 tablets of 5 mg/1000 mg. If the patient has no prior experience with diabetes medication, the initial therapy consists of taking 1 tablet of 5 mg/500 mg or 10 mg/500 mg once daily.

This medication is used to help control blood sugar and is mainly used in patients with diabetes. However, it should not be administered to patients with poor kidney function or those with severe infections or dehydration. This medication can rarely cause a serious metabolic complication called lactic acidosis, so patients and healthcare providers should be well aware of the symptoms of lactic acidosis. Also, there is a risk of hypoglycemia when used in combination with insulin or sulfonylureas, so caution is needed. This medication is not recommended for patients with moderate to severe impaired kidney function, and kidney function should be regularly monitored before and during treatment. Elderly patients or those with reduced fluid volume are at higher risk of dehydration or hypotension, so blood pressure and fluid status should be closely monitored. Additionally, this medication may increase the risk of genital and urinary tract infections, and immediate treatment should be sought if symptoms of infection appear. Women who are pregnant or breastfeeding should not use this medication, and treatment should be discontinued immediately if pregnancy is confirmed. Excessive alcohol consumption may increase the risk of lactic acidosis when taking this medication, so it should be avoided. If surgery or contrast agent examination is planned during the treatment period, it is necessary to consult the healthcare provider to consider discontinuation for a period. Also, this medication can cause vitamin B12 deficiency in some patients, so regular blood tests are recommended. Hypoglycemia symptoms may occur, so patients should pay attention to symptoms such as dizziness or lightheadedness, and consult a physician immediately if symptoms occur. This medication is not established for safety and efficacy in children, so it should not be used. Finally, this medication should be stored out of reach of children and kept in the original container to maintain quality.

Serious side effects

• Lactic acidosis
• severe hypoglycemia
• dehydration
• hypovolemia
• hypotension
• diabetic ketoacidosis
• ketosis
• urosepsis
• pyelonephritis
• acute kidney injury

Mild side effects

Hypoglycemia, dry mouth, dizziness, constipation, dry mouth, low back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, elevated serum creatinine at the beginning of treatment, elevated blood urea, weight loss, tendinitis, joint pain, muscle pain, myofascial pain syndrome, osteoarthritis, osteochondrosis, limb pain, periarticular inflammation, tendinitis, headache, paresthesia, tremor, epigastric pain, indigestion, abdominal discomfort, diarrhea, abdominal pain

This medication should be stored in a sealed container to prevent air or moisture from entering. It is recommended to maintain storage temperatures between 1°C and 30°C at room temperature.

Appearance

Yellow, biconvex, oval-shaped sustained-release film-coated tablet

Package unit

Bottle packaging - 30 tablets/bottle [(bottle: HDPE, cap: LDPE)], bottle packaging - 100 tablets/bottle [(bottle: HDPE, cap: LDPE)]