Tapagins Plus Sustained-release Tablet 10/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage of this medication is dapagliflozin 10 mg/sustained-release metformin 2000 mg as 2 tablets of 5 mg/1000 mg. The recommended starting dose for initial therapy is one tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, the dosage should be adjusted gradually.

This medication helps lower blood sugar. However, there are several precautions to take when using this medication. Firstly, this medication should not be used in patients with impaired kidney function. In cases of moderate or severe kidney impairment, this medication may accumulate in the body and pose risks. Patients who are dehydrated or have severe infections, heart issues, or acute myocardial infarction should also avoid this medication, as these conditions heighten the risk of side effects. Pregnant or breastfeeding women should not use this medication, nor should patients with certain genetic issues such as lactose intolerance. This medication may cause hypoglycemia when used with other diabetes treatments, so dosage adjustments are necessary when used in conjunction with insulin or sulfonylureas. While taking this medication, genital or urinary infections may occur, so immediate consultation with a physician is warranted if such symptoms arise. Additionally, this medication may cause decreased fluid volume or hypotension, so elderly patients or those taking diuretics should regularly check their blood pressure and fluid status. Due to the metformin component, rare but severe side effects such as lactic acidosis may occur, so if symptoms like fatigue, muscle pain, difficulty breathing, or abdominal pain occur, immediate communication with healthcare personnel is critical. It is safer for patients with liver or kidney impairment to avoid this medication. Regular assessments of kidney function should be conducted before and during the course of this medication, especially for older adults. Furthermore, it is dangerous to consume alcohol while taking this medication, so excessive drinking should be avoided. This medication should be temporarily discontinued when undergoing surgery or radiographic examinations with contrast agents and resumed only after confirming normal kidney function post-examination. In case of an overdose, immediate visit to a healthcare facility for appropriate treatment is necessary, and dialysis may be beneficial if required. Lastly, this medication has not established safety and effectiveness in children; therefore, it should not be used in this population. Caution is warranted while driving or operating machinery, as dizziness may occur during medication use. Keep this medication out of reach of children and store it in its original container.

Serious side effects

Guillain-Barré syndrome, bacterial pneumonia, sialadenitis, urinary sepsis, pyelonephritis, acute kidney injury, renal dysfunction, rash, acute cholecystitis, ketoacidosis, fever, perineal necrosis, atrial fibrillation, cardiac disorders, severe lactic acidosis, severe hypoglycemia, cardiovascular collapse, acute myocardial infarction, sepsis, severe allergic reactions, severe rash with high fever, blistering, skin peeling, pain in oral/eye mucosa, shortness of breath or respiratory difficulty

Mild side effects

Vulvovaginitis, glans inflammation and related genital infections, urinary tract infections, fungal infections, hypoglycemia (when used with sulfonylureas or insulin), dry mouth, dizziness, constipation, back pain, pain during urination, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, reduced initial renal creatinine clearance, dyslipidemia, elevated serum creatinine levels at the treatment onset, elevated serum urea, weight loss

Store this medication in a tightly closed container to avoid exposure to air or moisture, at room temperature between 1 and 30 degrees Celsius. This storage method helps maintain the medication’s effectiveness and safety.

Appearance

Pink, double convex, rectangular sustained-release film-coated tablet

Package unit

30 tablets/bottle