Daploem Sustained-release Tablets 10/1000 mg

Adult dose

The dosage of this drug is individualized based on the patient's current treatment, effectiveness, and tolerance, without exceeding the maximum recommended dose of dapagliflozin 10 mg and sustained-release metformin 2000 mg. Generally administered once daily with dinner. The maximum dosage is dapagliflozin 10 mg/sustained-release metformin 2000 mg once daily, provided as 2 tablets of 5 mg/1000 mg. For patients with prior diabetes history,

This drug may very rarely cause a serious condition called lactic acidosis. Therefore, patients with poor kidney function or issues with the heart or liver should be particularly cautious. Hypoglycemia may occur when this drug is used in conjunction with insulin or sulfonylureas, so patients taking such medications should closely monitor changes in blood sugar. This drug should not be administered to patients with moderate to severe renal impairment, dehydration, serious infections, or acute heart issues. Before and after surgery or tests involving radiographic contrast agents, the use of this drug should be discontinued for a certain period, and it should only be resumed once normal kidney function is confirmed. Pregnant or breastfeeding women should not take this drug, and it is contraindicated in patients with hereditary lactose intolerance. Caution should be exercised when administering this drug to patients with risks of reduced fluid volume or hypotension, especially to elderly patients or those with diminished kidney function, who should be regularly monitored for kidney function. There may be occurrences of genital infections or urinary tract infections during treatment, so patients should immediately inform healthcare professionals if related symptoms occur. Vitamin B12 deficiency may occur, so it is advisable to monitor vitamin B12 levels through blood tests during prolonged use. Excessive alcohol intake may increase the risk of side effects for this drug, so it should be avoided. If there is a failure in blood sugar control or abnormal symptoms during treatment, immediate consultation with a physician is required. This drug may interact with other medications, so it is important to inform healthcare professionals about all medications being taken and to undergo regular examinations. In case of overdose, immediate medical attention should be sought, and this drug can be removed by dialysis. While this drug does not significantly affect driving or operating machinery, caution is advised due to the possibility of dizziness and similar symptoms. Finally, this drug should be kept out of reach of children and stored in its original container.

Serious side effects

• Lactic acidosis
• severe edema
• hypoglycemia
• ketoacidosis
• acute kidney injury
• renal dysfunction
• urinary sepsis
• pyelonephritis
• perineal necrosis
• Guillain-Barré syndrome

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, diabetic ketoacidosis, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, elevated hematocrit, decreased renal creatinine clearance at the start of treatment, dyslipidemia, increased blood creatinine at the start of treatment, elevated blood urea, weight loss, Guillain-Barré syndrome, bacterial pneumonia

This drug should be stored in a tightly sealed container to prevent air or moisture from entering, and it is best stored at room temperature between 1 to 30 degrees Celsius. This way, the effectiveness of the drug can be maintained for a longer period.

Appearance

Yellow, oval, double-sided convex sustained-release film-coated tablets

Package unit

30 tablets/box [(6 tablets/PTP*5)], 30 tablets/bottle