Flogaduo Extended-Release Tablets 5/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dose is dapagliflozin 10 mg and extended-release metformin 2000 mg once daily, administered as 2 tablets of 5 mg/1000 mg. The recommended starting dose when used as initial therapy is one tablet of 5 mg/500 mg or 10 mg/500 mg taken once daily. Dosage should be gradually adjusted to minimize gastrointestinal side effects of metformin.

This medication is used for the treatment of diabetes and helps in controlling blood glucose levels. Caution is needed as a rare side effect called severe lactic acidosis may occur while taking this medication. Lactic acidosis can lead to dangerous conditions due to excessive accumulation of lactic acid in the body. Furthermore, when taken with insulin or sulfonylureas, there is a risk of hypoglycemia, so careful monitoring of blood glucose levels is necessary. Patients with certain health conditions such as impaired kidney function, dehydration, severe infections, or weakened heart function should not take this medication. Prior to and following surgical procedures or tests using iodine-based contrast agents, this medication should be temporarily discontinued, and it should be resumed only after confirming normal kidney function. Women who are pregnant or breastfeeding should not use this medication, and safety and efficacy have not been established for children. Caution is warranted for patients at risk of decreased fluid volume or hypotension, especially in elderly patients or those with reduced kidney function, who should have their kidney function monitored regularly. During treatment, genital or urinary infections may occur, so immediate consultation with healthcare professionals is recommended if related symptoms appear. This medication can lower vitamin B12 levels, so regular checks of vitamin B12 levels are advised for prolonged usage. Excessive alcohol consumption can increase the risk of side effects of this medication, so it should be avoided. Due to the risk of hypoglycemia, any symptoms of hypoglycemia (such as dizziness, cold sweat, severe fatigue, etc.) should be addressed immediately, and dosage adjustments may be necessary when taken with insulin or other hypoglycemic agents. Symptoms of dehydration or hypotension may occur while taking this medication, so adequate fluid intake and blood pressure management are important. This medication does not significantly affect driving or the operation of machinery, but caution should be exercised due to possible dizziness. It is crucial to adhere to the prescribed methods and dosages while taking the medication and to receive regular check-ups as directed by a healthcare provider. Keep out of the reach of children and store in the original container to maintain quality.

Serious side effects

• Severe lactic acidosis
• severe hypoglycemia
• lactic acidosis
• acute renal failure
• diabetic ketoacidosis
• urosepsis and pyelonephritis
• renal impairment
• Guillain-Barré syndrome
• atrial fibrillation
• acute cholecystitis

Mild side effects

• Vulvitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• dry mouth
• dizziness
• constipation
• back pain
• dysuria

This medication should be stored in a tightly closed container to avoid exposure to air or moisture, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the efficacy of the medication over time.

Appearance

Orange, biconvex, egg-shaped film-coated tablet

Package unit

30 tablets/bottle