Sitagliptin and Metformin Extended-Release Tablets 100/1000 mg

Adult dose

The 100/1000 mg extended-release tablet is taken once daily, one tablet at a time. Patients taking the 50/500 mg extended-release tablet or the 50/1000 mg extended-release tablet should take two tablets at a time once daily. 1. For patients currently not treated with metformin: The initial total dosage is sitagliptin 100 mg and metformin 1000 mg daily. If the initial dose does not provide sufficient blood sugar control, dose adjustments may be made.

This medication contains two ingredients: sitagliptin and metformin. First, sitagliptin can rarely cause serious allergic reactions, including anaphylaxis, angioedema, and skin disorders. If any of these symptoms occur, stop taking this medication immediately and consult a doctor. Also, sitagliptin may cause acute pancreatitis, so patients should be monitored carefully for symptoms such as abdominal pain or vomiting during treatment. Metformin can cause a rare but potentially fatal metabolic complication called lactic acidosis. Symptoms may manifest as nonspecific symptoms such as muscle pain, weakness, shortness of breath, and abdominal pain, so it is essential to inform a doctor immediately if these symptoms occur. Additionally, this medication should not be administered to patients with impaired kidney function, liver disorders, severe infections, or dehydration. This medication may need to be temporarily discontinued before and after certain tests or surgeries. Especially before and after tests using iodinated contrast media, kidney function needs to be checked before resuming administration. Regular monitoring of kidney function, blood tests, and vitamin B12 levels is essential during treatment. Excessive alcohol consumption should be avoided during treatment as it may increase the risk of lactic acidosis. There is a risk of hypoglycemia, so special attention should be paid to hypoglycemic symptoms, particularly when taking other antidiabetic medications such as insulin or sulfonylureas. Irregular meals, vigorous exercise, or nutritional imbalances can also increase the risk of hypoglycemia. If symptoms such as severe joint pain or skin blisters occur, inform a doctor immediately, and discontinuation of the medication may be necessary. This medication is not to be used in women who are pregnant or may become pregnant, nursing mothers, or children under 18 years old. The elderly should have their kidney function assessed prior to taking this medication as renal function may decrease and regular monitoring is required. In case of overdose, consult a healthcare provider immediately, and blood dialysis or other treatments may be necessary if required. This medication may interact with various other drugs, so it is important to inform the healthcare provider of any other medications being taken.

Serious side effects

Rash, severe hypersensitivity reactions (including anaphylaxis, angioedema, Stevens-Johnson syndrome, and exfoliative dermatitis), acute pancreatitis, severe lactic acidosis, acute renal failure, severe joint pain with disability, bullous pemphigoid, elevated liver enzymes, anaphylaxis, angioedema, rash, urticaria, cutaneous vasculitis, Stevens-Johnson syndrome, acute renal failure, severe joint pain with disability, bullous

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nasopharyngitis
• nausea
• vomiting
• abdominal pain
• myalgia
• limb pain
• back pain

Store this medication in a tightly closed container to prevent air or moisture ingress, at a temperature between 1°C and 30°C. Proper storage helps maintain the medication’s effectiveness for a prolonged period.

Appearance

Light blue, oval-shaped, convex, extended-release film-coated tablets

Package unit

28 tablets/bottle, 56 tablets/bottle, 200 tablets/bottle