Januritin Combo Sustained Release Tablet 100/1000 mg

Adult dose

For this medication containing 100/1000 mg sustained-release tablet, take one tablet once daily. For patients taking 50/500 mg sustained-release tablet or 50/1000 mg sustained-release tablet, take two tablets at the same time once daily. 1. For patients not currently treated with metformin: The initial dose of this medication is a total daily dose of 100 mg of sitagliptin and 1000 mg of metformin. If adequate blood glucose control is not achieved with the initial dose, dosage adjustment may occur.

This medication contains sitagliptin and metformin and is used in the treatment of diabetes. Firstly, this drug may cause severe allergic reactions in some patients, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur within three months of the initial dose, you must stop taking this medication immediately and seek medical attention. Acute pancreatitis, which is an inflammation of the pancreas, may occur, so you should inform healthcare professionals immediately if you experience sudden abdominal pain, nausea, or vomiting. Patients with moderate to severe renal impairment, serious infections, dehydration, heart failure, or acute myocardial infarction should not take this medication. In particular, this medication should be temporarily discontinued before and after tests involving iodinated contrast agents to reduce the risk of renal function deterioration and lactic acidosis. Resumption of use should occur only after normal renal function is confirmed post-examination. Women who are pregnant or may become pregnant, and nursing mothers should not take this medication, and safety in children under 18 has not been established. This medication has the potential to cause lactic acidosis, a rare but serious metabolic disturbance, so if you experience sudden fatigue, muscle pain, difficulty breathing, abdominal pain, or changes in consciousness, you must immediately inform a doctor. Additionally, alcohol consumption can increase the risk of side effects from this medication; therefore, it is advisable to avoid drinking during treatment. There is a risk of hypoglycemia, so care should be taken if meals are skipped, if meals are irregular, or if excessive exercise occurs, and symptoms of hypoglycemia should be carefully monitored when taken with other hypoglycemic agents. During treatment with this medication, regular monitoring of renal function and blood tests is necessary, and vitamin B12 levels may drop, so these should be checked and supplemented if necessary. If surgery is planned, this medication should be discontinued 48 hours before surgery, and it should only be resumed after confirming that renal function is normal post-surgery. Lastly, if you develop blisters or rashes on your skin or severe joint pain during treatment with this medication, you should inform your doctor immediately, as these symptoms may require discontinuation of the drug.

Serious side effects

Hives, angioedema, anaphylaxis, exfoliative skin conditions, Stevens-Johnson syndrome, acute pancreatitis, acute renal failure, lactic acidosis, severe and disabling joint pain, bullous pemphigoid, increased liver enzyme levels, liver abnormalities (risk of jaundice), severe allergic reactions, acute pancreatitis, acute renal failure, severe skin abnormal reactions, thrombocytopenia, rhabdomyolysis, serious neurological symptoms (seizures, confusion of consciousness, etc.)

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and it is safe to store at room temperature between 1 and 30 degrees Celsius. By doing so, you can maintain the effectiveness of the medication for a longer duration.

Appearance

A bright blue, oval-shaped sustained-release film-coated tablet with a convex surface on both sides

Package unit

28 tablets/bottle, 200 tablets/bottle, 56 tablets/bottle