Ozempic Pre-filled Pen (Semaglutide)

Adult administration

The starting dose of this medication is 0.25 mg of semaglutide once weekly. After 4 weeks, the dose is increased to 0.5 mg once weekly. After at least 4 weeks of administration at this dose, if additional blood sugar control is needed, the dose may be increased to 1 mg once weekly. It is not recommended to exceed a dose of 1 mg once weekly. This medication should be administered once weekly and can be taken at any time of the day regardless of meals.

This medication should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. It is not a substitute for insulin, and caution is needed as patients who are insulin-dependent may develop diabetic ketoacidosis if they abruptly discontinue or reduce insulin when starting this medication. Those with hypersensitivity to any ingredients or additives of this medication should not use it. It is not recommended for patients with severe heart failure, and caution should be exercised in patients with impaired renal function as gastrointestinal side effects may lead to dehydration or worsening of kidney function. If symptoms of acute pancreatitis appear, the medication should be discontinued immediately, and patients with a history of pancreatitis should be particularly cautious. The risk of hypoglycemia increases when used in conjunction with sulfonylureas or insulin, thus dose adjustment of those medications should be considered when starting this therapy. Regular eye examinations are advised for patients with diabetic retinopathy as the risk of complications may increase during treatment. Women who are pregnant or planning to become pregnant should not use this medication, and it should be avoided in breastfeeding. Elderly patients or those with slightly decreased renal or liver function do not require dose adjustment, but it is not recommended for patients with end-stage kidney disease. This medication is administered by injection, and training on injection techniques is required before use; syringes should be replaced with a new one each time to prevent infection or side effects. When storing the medication, keep it refrigerated between 2°C and 8°C, avoiding freezing and direct light exposure, and use it within 6 weeks after opening. This medication may affect the absorption of oral medications, so caution is needed when taken with other oral drugs. Additionally, while this medication does not significantly affect driving or operating machinery, caution should be exercised if there is a risk of hypoglycemia. In cases of overdose, there is no specific antidote, and appropriate treatment should be based on symptoms, with long-term monitoring possible.

• Nausea
• diarrhea
• vomiting
• abdominal pain
• abdominal distension
• constipation
• indigestion
• gastritis
• gastroesophageal reflux disease
• belching

Store this medication in a sealed container to avoid exposure to air, and keep it refrigerated between 2°C and 8°C, avoiding freezing. It is also advisable to store it in a dark place away from direct light.

Appearance

A transparent liquid in a colorless, transparent cartridge attached to a dose-adjustable pre-filled pen.

Package unit

1 pre-filled pen/box [pre-filled pen (1.5mL)], 1 pre-filled pen/box [pre-filled pen (3mL)]