Zadiembaduo Tablet 5/850 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage is 1 tablet once, twice a day. The maximum recommended daily dosage for each ingredient should not exceed 25 mg of Empagliflozin and 2000 mg of Metformin, based on the individual patient's current treatment regimen, efficacy, and tolerability. For patients not achieving adequate blood sugar control with Metformin alone or in combination therapies with insulin or other medications, the recommended dose is 5 mg of Empagliflozin twice a day (total daily amount)

This medicine may cause a rare but serious side effect called severe lactic acidosis, so it should not be administered to patients with impaired kidney function, severe infections, or dehydration. Care should be taken if used together with other diabetes medications such as insulin or sulfonylureas as there is a risk of hypoglycemia. Patients with impaired kidney function, acute heart failure, pregnant women, breastfeeding women, and patients with severe liver dysfunction should not take this medicine. If undergoing tests using iodine contrast agents, this medicine should be discontinued before the test and can be resumed only after confirming that kidney function returns to normal. This medicine may increase the risk of urinary tract infections and genital infections, so immediate consultation with healthcare professionals is required if related symptoms occur. Patients at risk of decreased fluid volume, such as those with dehydration or cardiovascular disease, should be carefully monitored for blood pressure and fluid status while taking this medicine. Vitamin B12 levels may decrease, so patients taking this medicine for a long period are advised to regularly check their vitamin B12 levels. Excessive alcohol consumption should be avoided while taking this medicine, as alcohol can increase the risk of lactic acidosis. Elderly patients or those with deteriorating kidney function may require dose adjustment and regular kidney function tests. During treatment, blood sugar control levels should be monitored consistently, and immediate action should be taken if hypoglycemic symptoms occur. If surgery is planned or prolonged fasting is needed due to acute illness, the use of this medicine should be temporarily halted, and restarted once the condition stabilizes. This medicine has not been confirmed for safety and efficacy in children, so it is not recommended for those under the age of 18. If symptoms such as fever, pain in the groin or perineum, swelling, skin rashes occur while taking this medicine, immediate medical attention is required, especially concerning severe infection symptoms like perineal necrosis. In case of overdose, swift medical attention is necessary, and for Metformin, the medication can be removed via hemodialysis. This medicine should be kept out of the reach of children and stored in its original container for safety.

Serious side effects

Urticaria, angioedema, perineal necrosis, ketoacidosis, lactic acidosis, cerebral infarction, myocardial infarction, heart failure, acute kidney injury, acute renal failure, urosepsis, pyelonephritis, liver abnormalities (hepatitis, acute cholecystitis, autoimmune hepatitis), severe allergic reactions, severe skin adverse reactions, severe rash with fever, blistering, skin peeling, pain in oral/ocular mucosa, difficulty breathing, asthma attacks, cough accompanied by fever

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medicine may be sensitive to air and moisture, so it must be stored in a tightly sealed container. Ideally, store at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's efficacy for a longer period.

Appearance

White, oval-shaped film-coated tablet with a yellowish hue, double convex

Package unit

60 tablets/box (10 tablets/PTP x 6), 10 tablets/box (10 tablets/PTP x 1), 60 tablets/bottle, 30 tablets/bottle