Tenelia M Extended-Release Tablet 10/500 mg (Teneligliptin Hydrate, Metformin Hydrochloride)

Adult dose

This medication is generally administered once daily with the evening meal, and the dosage is gradually adjusted to minimize gastrointestinal side effects related to metformin. The 20/1000 mg extended-release tablet is taken once daily, with one tablet at a time. Patients taking the 10/750 mg or 10/500 mg extended-release tablet should take it once daily, with two tablets at the same time. For patients unable to achieve sufficient blood sugar control with metformin monotherapy, the initial dosage of this medication should provide teneligliptin 20 mg once daily along with the existing dosage of metformin. In patients transitioning from teneligliptin and metformin combination therapy to this medication, the dosage may begin at the existing doses of teneligliptin and metformin. When converting from immediate-release metformin to extended-release formulation, glycemic control should be closely monitored and dosage adjustments made appropriately. When used in combination with sulfonylureas, consideration may be given to reducing the sulfonylurea dose to minimize the risk of hypoglycemia. The maximum recommended daily dose is teneligliptin 20 mg and extended-release metformin 2000 mg. The safety and efficacy of this medication have not been specifically assessed in patients switching from other hypoglycemic agents. Changes in blood sugar control should be carefully monitored during treatment for type 2 diabetes. To maintain the extended-release characteristics, this medication should be swallowed whole and not divided, crushed, chewed, or broken.

This medication is used in the treatment of diabetes and acts to lower blood sugar levels. However, it can rarely cause a serious metabolic complication known as lactic acidosis, which requires caution. The risk of lactic acidosis is higher in patients with impaired kidney function or who have poor heart, liver, or lung function. Additionally, if taken in conjunction with insulin or sulfonylurea medications, symptoms of hypoglycemia may occur, so careful monitoring of blood sugar levels is necessary. It is safer not to use this medication in patients with moderate to severe kidney impairment, heart failure, acute myocardial infarction, severe infections, or those scheduled for surgery. Patients with a history of abdominal surgery or bowel obstruction, as well as those with heart problems such as prolonged QT interval, should also be prescribed this drug with caution. Some patients have reported side effects such as constipation, abdominal pain, liver dysfunction, acute pancreatitis, skin rashes, etc., so immediate consultation with a physician is necessary if any abnormal symptoms occur. Pregnant women, those who may become pregnant, and nursing mothers are recommended not to use this medication. Elderly patients may experience decreased kidney function and should undergo regular kidney function tests and dosage adjustments. Also, since the risk of lactic acidosis may increase if taken with alcohol, it is advisable to avoid alcohol consumption. Patients need to exercise caution when performing tasks requiring concentration, such as driving or operating machinery, due to the risk of hypoglycemia. Finally, it is important to regularly evaluate blood tests and kidney function tests for abnormalities while taking this medication.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, sweating, pallor, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, drastically reduced urine output

Mild side effects

• Hypoglycemia
• constipation
• dizziness
• abdominal distension
• abdominal discomfort
• nausea
• abdominal pain
• bloating
• stomatitis
• gastric polyp

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, and it is safe to keep it at room temperature between 1°C and 30°C. This storage method helps maintain the effectiveness of the medication for a longer period.

Appearance

Orange oval extended-release film-coated tablet

Package unit

Bottle - 30 tablets/bottle