Poshuvet Tablet 10 mg (Dapagliflozin Propanediol Hydrate)

Adult dose

The recommended dose for this medication is 10 mg once daily for both monotherapy and additional combination therapy with other hypoglycemic agents such as insulin. In initial combination therapy where there is no prior experience with diabetes medications, the initial recommended dose with metformin is 5 mg or 10 mg once daily. The same 10 mg dose is also recommended for patients with chronic heart failure and chronic kidney disease. For renal impairment, liver impairment, and in the elderly

Child dose

The efficacy and safety of dapagliflozin in children under 18 years have not been established. There is no related information.

This medication should not be used in patients who are allergic to the active ingredient or excipients. It should not be administered to patients with type 1 diabetes or diabetic ketoacidosis. It contains lactose anhydrous and should not be used in patients with genetically-related issues such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. Patients undergoing dialysis should also avoid this medication. Caution should be exercised in patients with decreased fluid volume or impaired kidney function. Especially, symptomatic hypotension or abrupt changes in kidney function may occur, so fluid status and kidney function should be evaluated before administration and symptoms of hypotension and kidney function should be closely monitored during administration. This medication may have varying effects on blood sugar control depending on kidney function, and it is not recommended to be used for blood sugar control in cases of moderate to severe renal impairment. During treatment with this medication, side effects such as genital infections, urinary tract infections, hypoglycemia, reduced fluid volume, and diabetic ketoacidosis may occur. Genital infections are particularly common in women and may recur if there is a history of infections. This medication may lower blood pressure, so elderly patients or those on diuretics should be cautious of dehydration and hypotension. In rare cases, severe genital or perineal pain, swelling, redness may indicate a serious infection called Fournier's gangrene, which should be reported to healthcare professionals immediately. Women who are pregnant or planning to become pregnant should not use this medication, and nursing mothers should avoid taking it as well. This medication may increase the risk of hypoglycemia when used with insulin or sulfonylureas, so dose adjustment may be needed if used together. In case of overdose, there is no specific antidote, and appropriate treatment should be provided based on symptoms; it is not removed by dialysis. Lastly, the safety and efficacy of this medication in pediatric patients have not been established, hence it should not be used in this population. While taking this medication, avoid alcohol consumption, undergo regular blood sugar and kidney function tests, and consult with healthcare professionals if abnormal symptoms appear.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy all over, sudden and very severe headaches, thunderclap headaches, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, increased hematocrit, dyslipidemia, elevated serum creatinine, elevated blood urea, weight loss, gastrointestinal disorders (gastroesophageal reflux disease, upper abdominal pain, diverticulitis, bowel perforation, acute pancreatitis, chronic pancreatitis, gastritis, dyspepsia, nausea, diarrhea, vomiting, abdominal discomfort

This medication should be stored in a tightly closed container to avoid exposure to air or moisture, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. This storage will help maintain the effectiveness of the medication and prevent deterioration.

Appearance

Yellow, biconvex, diamond-shaped film-coated tablets

Package unit

28 tablets (14 tablets/PTP×2)