Verkubojeng 5 mg (Vericiguat (Unformulated))

Adult dose

1. Adults The recommended starting dose of this medicine is 2.5mg once daily. Take with food. Depending on the patient's tolerability, double the dose approximately every 2 weeks until the target maintenance dose of 10mg once daily is reached. If the patient does not tolerate the medicine well (systolic blood pressure below 90 mmHg or symptomatic hypotension), reduce the dose or discontinue treatment. Do not initiate treatment with this medicine if systolic blood pressure is below 100 mmHg. For patients unable to swallow the tablet whole, this medicine may be crushed and mixed with water immediately before taking it. (See 11. Information for healthcare professionals, 2) Pharmacokinetic information) Missed dose: If a dose is missed, take it as soon as possible on the same day. Do not take this medicine twice on the same day. 2. Older adults No dose adjustment is necessary in older adults. (See 9. Use in older adults and 11. Information for healthcare professionals, 2) Pharmacokinetic information) 3. Patients with renal impairment No dose adjustment is necessary in patients with eGFR≥15mL/min/1.73m2 who are not receiving dialysis. This medicine has not been studied in patients with eGFR<15 mL/min/1.73m2 or in patients receiving dialysis at treatment initiation; therefore, it is not recommended for these patients. (See 11. Information for healthcare professionals, 2) Pharmacokinetic information) 4. Patients with hepatic impairment No dose adjustment is necessary in patients with mild or moderate hepatic impairment. This medicine has not been studied in patients with severe hepatic impairment; therefore, it is not recommended for these patients. (See 11. Information for healthcare professionals, 2) Pharmacokinetic information)

This medication should not be used in pregnant women as it may harm the fetus. Women of childbearing potential should confirm their pregnancy status before taking this medication, and should use appropriate contraceptive methods during and for one month after treatment. Patients allergic to any of the components of this medication, those taking other medications with similar effects, and those with genetic lactose metabolism disorders should not use this medication. Patients whose blood pressure is too low or who exhibit symptoms of hypotension at the start of treatment should use this medication with caution, and care is needed when using it in combination with certain cardiac treatment medications or antihypertensive agents. It is not recommended for patients with severely impaired kidney function or serious liver disease. This medication may cause side effects such as anemia, digestive disorders, dizziness, headache, and hypotension, so if symptoms are severe, the patient should consult a physician. Particularly in patients with low blood pressure, symptomatic hypotension may occur, so blood pressure should be carefully monitored, and dosage may need to be reduced or treatment stopped if necessary. This medication may interact with certain antihypertensive agents or heart disease medications, so if taking other drugs, it is essential to inform and consult a healthcare professional. It should not be used during pregnancy as it may be harmful to the fetus, and breastfeeding women should discontinue breastfeeding during treatment. Safety and effectiveness in pediatric patients have not been adequately established, so it is advisable not to use it in children. There is no need for special dosage adjustments in elderly patients, but they may be more sensitive to side effects, so caution is needed. In the case of overdose, hypotension may occur, so the patient should seek immediate medical attention, as this medication is not easily removed by hemodialysis.

• Anemia
• nausea
• indigestion
• vomiting
• gastroesophageal reflux disease
• dizziness
• headache
• hypotension
• symptomatic hypotension

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is best kept in a cool place between 2 and 30 degrees Celsius. Avoid storing in direct sunlight or excessively hot areas.

Appearance

Biconvex reddish-brown round film-coated tablet

Package unit

For domestic use - 28 tablets/box [(14 tablets/blister X 2)]