Medication info

Tetraffepir Injection

Prescription medicationInjections
Ingredient · strength
L-Leucine›0.74g / 100mLL-Lysine Acetate›0.93g / 100mLL-Methionine›0.43g / 100mLL-Valine›0.62g / 100mLL-Serine›0.65g / 100mLL-Arginine›1.2g / 100mLL-Alanine›1.4g / 100mLL-Isoleucine›0.5g / 100mLL-Threonine›0.44g / 100mLL-Tryptophan›0.2g / 100mLL-Tyrosine›0.04g / 100mLL-Phenylalanine›0.51g / 100mLL-Proline›1.12g / 100mLL-Histidine›0.3g / 100mLAnhydrous Sodium Glycerophosphate›0.418g / 100mLGlycine›1.1g / 100mLSodium Acetate Hydrate›0.562g / 100mLPotassium Chloride›0.448g / 100mLCalcium Chloride Hydrate›0.074g / 100mLTaurine›0.1g / 100mLMagnesium Sulfate Hydrate›0.247g / 100mLZinc Sulfate Hydrate›0.0023g / 100mLGlucose Monohydrate›14.3g / 100mLSoybean Oil›6g / 100mLPurified Fish Oil (High Dose Omega-3 Fatty Acids)›3g / 100mLPurified Olive Oil›5g / 100mLTriglycerides Medium-Chain›6g / 100mL
Manufacturer / importer
대한약품공업(주)
Appearance
Consists of a colorless, transparent plastic inner bag divided into 3 compartments and an outer packaging, with an oxygen absorber in between. Each inner bag contains a colorless to pale yellow transparent amino acid solution.
Packaging
217 mL/bag (A solution: 68 mL, B solution: 118 mL, C solution: 31 mL), 241 mL/bag (A solution: 76 mL, B solution: 131 mL, C solution: 34 mL), 362 mL/bag (A solution: 114 mL, B solution: 197 mL, C solution: 51 mL), 500 mL/bag (A solution: 157.5 mL, B solution: 272 mL, C solution: 70.5 mL), 603 mL/bag (A solution: 190 mL, B solution: 328 mL, C solution: 85 mL), 1206 mL/bag
Approval status
Active

MFDS item code 202106268 · Notified 2021.09.01

Summary

Main use
Treatment for calorie and essential fatty acid supply when oral or gastrointestinal nutrition is not possible
Who uses it
Adults · Children
Adult dosage
Children aged 12 years and older and adults - Normal nutritional state or patients with mild metabolic stress: 0.6-0.9 g/kg of amino acids (0.10-0.15 g/kg of nitrogen) per day - Patients with moderate to severe metabolic stress: 0.9-1.6 g/kg of amino acids (0.15-0.25 g/kg of nitrogen) per day Dosage: 20-40 mL/kg per day (0.6-1.3 g/kg of amino acids, 0.10-
Children's dosage
Children aged 2-11 years Dosage: Regularly adjusted according to needs, up to a maximum of 40 mL/kg per day Administration rate: Do not exceed 3.0 mL/kg per hour Recommended administration duration: 12-24 hours Minimum administration duration (recommended

Ingredients

Manufacturer
대한약품공업(주)

Efficacy & effects

Treatment for calorie and essential fatty acid supply when oral or gastrointestinal nutrition is not possible

View approved original text

This medication provides calories, amino acids, essential fatty acids, and omega-3 fatty acids intravenously to pediatric and adult patients over 2 years old, when oral or gastrointestinal nutrition is difficult. It helps improve patients' nutritional status and maintain balanced nutrition. It is primarily used to address insufficient nutrition in patients and to support recovery.

Dosage and Administration

Adult dosage

Children aged 12 years and older and adults - Normal nutritional state or patients with mild metabolic stress: 0.6-0.9 g/kg of amino acids (0.10-0.15 g/kg of nitrogen) per day - Patients with moderate to severe metabolic stress: 0.9-1.6 g/kg of amino acids (0.15-0.25 g/kg of nitrogen) per day Dosage: 20-40 mL/kg per day (0.6-1.3 g/kg of amino acids, 0.10-

Children's dosage

Children aged 2-11 years Dosage: Regularly adjusted according to needs, up to a maximum of 40 mL/kg per day Administration rate: Do not exceed 3.0 mL/kg per hour Recommended administration duration: 12-24 hours Minimum administration duration (recommended

Precautions

This medication must be used strictly according to a doctor's instructions, and should not be stopped or changed based on self-judgment. If allergic reactions such as fever, chills, skin rash, or difficulty breathing occur, discontinue administration immediately and inform medical personnel. Caution is necessary as dangerous precipitates can occur when used with other intravenous calcium-containing products or certain antibiotics; do not administer them simultaneously. Particularly, this medication may be risky for premature infants or low-birth-weight infants, and should be avoided in cases of severe respiratory illness. Patients with allergies to fish, eggs, soybeans, peanuts, or patients with severely impaired liver or kidney function, and patients in acute shock should not use this medication. It should not be administered to children under 2 years of age. Patients with impaired kidney function, diabetes, or liver dysfunction should be particularly cautious when using this medication and should administer it under strict medical supervision. During administration, regular checks of lipid levels, electrolyte concentrations, blood glucose, and liver enzyme levels in the blood should be conducted to ensure no abnormalities exist. Overdose may lead to hyperlipidemia, hyperglycemia, allergic reactions, etc., and the rate and dosage of administration must be strictly adjusted. Aseptic conditions must be maintained to prevent infections during administration and the injection site should be frequently monitored to avoid thrombosis or inflammation. Women who are pregnant or breastfeeding should only use this medication under medical judgment due to insufficient assurance of safety.

Side effects and when to seek care immediately

Serious side effects

Anaphylactic reactions (fever, chills, rash, difficulty breathing), hives, difficulty breathing, skin rash, hives, cyanosis, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, severe mucosal pain in mouth/eyes, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough + fever, respiratory issues, yellowing of skin or eyes (jaundice), malaise

Mild side effects

  • Loss of appetite
  • nausea
  • vomiting
  • increased plasma liver enzyme levels
  • thrombophlebitis
  • hypotension
  • hypertension
  • mild increase in body temperature
  • chills
  • headache
Show 23 more
  • dizziness
  • skin rash
  • hives
  • flushing
  • headache
  • sensations of heat or cold
  • cyanosis
  • pallor
  • pain (neck, back, bone, chest, waist)
  • nausea
  • vomiting
  • chills
  • sweating
  • increased body temperature
  • hyperglycemia
  • constipation
  • diarrhea
  • pneumonia
  • stomatitis
  • delirium
  • dyspepsia
  • abdominal pain
  • hypoalbuminemia

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a sealed container to prevent air exposure and kept in a cool place below 25 degrees Celsius. Take care not to freeze, as freezing may change the components of the medication.

Appearance and packaging

Appearance

Consists of a colorless, transparent plastic inner bag divided into 3 compartments and an outer packaging, with an oxygen absorber in between. Each inner bag contains a colorless to pale yellow transparent amino acid solution.

Package unit

217 mL/bag (A solution: 68 mL, B solution: 118 mL, C solution: 31 mL), 241 mL/bag (A solution: 76 mL, B solution: 131 mL, C solution: 34 mL), 362 mL/bag (A solution: 114 mL, B solution: 197 mL, C solution: 51 mL), 500 mL/bag (A solution: 157.5 mL, B solution: 272 mL, C solution: 70.5 mL), 603 mL/bag (A solution: 190 mL, B solution: 328 mL, C solution: 85 mL), 1206 mL/bag

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.