Vildagliptin/Metformin Tablet 50/500 mg (Vildagliptin, Metformin)

Adult dosage

For the treatment of type 2 diabetes, the dosage of this medication should be individualized based on efficacy and tolerance within the limits of 100 mg of vildagliptin and 2000 mg of metformin. A dosage of more than 100 mg of vildagliptin per day is not recommended. This medication is generally administered with food or immediately after meals to reduce gastrointestinal adverse reactions caused by metformin.

This medication may cause severe lactic acidosis or hypoglycemia, so caution is required. It should not be used in patients with moderate or severe renal impairment, heart failure, acute myocardial infarction, or sepsis. Prior to examinations using radiographic contrast agents, this medication should be stopped at least 48 hours beforehand, and should only be resumed after confirming normal kidney function post-examination. It should not be administered to individuals allergic to this medication or its components, type 1 diabetes patients, or patients with diabetic ketoacidosis. In cases of severe infections, trauma, or around surgery, it should be temporarily discontinued and resumed only after recovery. Caution is also necessary in patients with poor nutritional status, liver dysfunction, or those who consume excessive alcohol. Pregnant or breastfeeding women should not take this medication. Irregular meals, vigorous exercise, and interactions with other medications can increase the risk of hypoglycemia or lactic acidosis, so caution is advised. During treatment, headaches, dizziness, nausea, and hypoglycemic symptoms may occur; if symptoms are severe, consult a physician. If liver abnormalities are suspected, regular liver function tests should be conducted, and if abnormalities are found, medication should be discontinued. If renal function is impaired or concomitant drugs that may affect renal function are used, kidney function should be monitored frequently. If symptoms of acute pancreatitis appear, the medication should be stopped immediately and medical attention should be sought. In case of overdose, immediate medical treatment should be sought; blood dialysis may be helpful if necessary. The use of this medication is not recommended for children and adolescents under 18 years of age. Elderly patients may be at risk of decreased renal function, so dosage adjustments and monitoring of renal function are necessary. Alcohol may increase the risk of lactic acidosis, so drinking should be avoided while on this medication. Caution is advised when driving or operating machinery as dizziness or hypoglycemic symptoms may occur. Blood glucose and glycosylated hemoglobin levels should be regularly monitored to assess treatment effectiveness. Blood tests should be performed to check vitamin B12 levels, and appropriate action should be taken if abnormalities are found. If skin reactions such as blisters or ulcers occur during the course of this medication, inform a doctor immediately and seek treatment.

Serious side effects

Hives, severe swelling (angioedema), severe allergic reactions, hepatitis, liver dysfunction, jaundice, acute pancreatitis, blistering and exfoliative skin lesions, bullous pemphigoid, severe edema, lactic acidosis, severe skin reactions, severe and disabling joint pain, serious neurological symptoms (severe headache, seizures, confusion), hypoglycemia (including severe hypoglycemia), respiratory issues (difficulty breathing, asthma attacks, respiratory abnormalities)

Mild side effects

• Headache
• dizziness
• tremors
• nausea
• fatigue
• gastroesophageal reflux
• diarrhea
• bloating
• chills
• reduced blood sugar

This medication is sensitive to air and moisture; therefore, it should be stored in a tightly sealed container at room temperature between 1 and 30 degrees Celsius. This helps maintain the medication's efficacy and prevents degradation.

Appearance

Bright yellow oval film-coated tablet

Package unit

30 tablets/bottle