Unimin 8.5%

Adult dosage

Adults: Administer by drip infusion at a maximum dosage of 1 to 1.5 g per day per kilogram of body weight. Administration speed: A concentration of about 10 g as total amino acids over 60 minutes is preferable, and the principle is to infuse at 30–40 drops per minute.

Children's dosage

Children: Administer by adjusting the dosage and infusion rate.

This medication should be used strictly according to a doctor's instructions. It should not be used in patients with hepatic coma or at risk of hepatic coma, severe renal impairment, hypernitrogenemia, metabolic disorders with problems utilizing nitrogen, cachectic heart disease, pulmonary edema, patients with oliguria or anuria, patients with hypernatremia and hyperchloremia or alkalosis, and patients with a history of myocardial infarction. Caution is required when administering this drug to patients with severe acidosis, congestive heart failure, edema due to sodium retention, hyperkalemia, patients with potassium retention, and those with liver or kidney impairment. This drug contains sodium bisulfite, which may cause allergic reactions or asthma attacks in patients allergic to sulfites or with asthma, so caution is advised. Allergic reactions such as rash may rarely occur; in such cases, administration should be stopped immediately. Gastrointestinal symptoms may include nausea or vomiting, and cardiovascular symptoms may include chest discomfort, palpitations, rapid heartbeat, and elevated blood pressure. Rapid administration of large doses may cause acidosis, so caution is necessary. Other symptoms may include chills, fever, headache, difficulty breathing, shock, bronchospasm, and urinary tract spasms. Metabolic complications may include metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, dehydration, hypoglycemia, elevated liver enzymes, vitamin deficiencies or excesses, electrolyte imbalances, and pediatric hyperammonemia. Patients with liver or kidney failure may experience elevated blood urea nitrogen (BUN) levels, and those with liver failure may show serum amino acid imbalances, metabolic alkalosis, systemic hypernitrogenemia, hyperammonemia, consciousness disturbances, or coma. Caution is advised for electrolyte imbalances during large dose administration, and metabolic alkalosis may occur with overdose. Patients with kidney disease, lung disease, or severe heart conditions should avoid excessive fluid administration, and diabetic patients should monitor their blood glucose levels frequently. When used with tetracycline antibiotics, the protein-sparing effect of this drug may be reduced. Sufficient safety has not been established in pregnant women; it should only be administered when the therapeutic benefits outweigh the risks. In children, since liver function may be immature, maintain lower concentrations and check blood ammonia levels frequently. Elderly patients may experience decreased physiological functions, so caution should be taken with slower administration rates and reduced doses. This drug contains electrolytes, so caution is needed regarding electrolyte balance during large dose administration, and it must be administered slowly intravenously. Rapid infusion can trigger chills and vomiting, and may increase amino acid loss to the kidneys. It is recommended to adjust the temperature to body temperature before use, and the preparation and handling of the infusion should be done in an aseptic manner. Do not use residual liquid or opaque solutions, and use immediately after mixing, storing in the refrigerator for no more than 24 hours. If crystals precipitate, heat to 50–60 degrees, then cool to body temperature before use. For storage, keep the package sealed away from light, and do not use if the solution is discolored or leaked. Ensure proper measuring from the container.

Serious side effects

Chest tightness, difficulty breathing, respiratory arrest, asthma attacks, shock, bronchospasm, severe allergic reactions (anaphylactic shock), severe edema accompanied by elevated blood pressure, liver failure, kidney failure, coma, severe neurological symptoms (confusion of consciousness)

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• accelerated heart rate
• elevated blood pressure
• chills
• fever
• headache

This medication should be stored in a sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness and safety.

Appearance

A colorless to light yellow transparent liquid filled in a plastic container for injection.

Package unit

250 milliliters / box