Vancomycin Injection 1 Gram (vancomycin hydrochloride)

Adult dosage

Adults: Administer 500 mg (activity) of vancomycin intravenously every 6 hours or 1g (activity) every 12 hours by slow intravenous infusion. For oral administration, adults generally receive 500 to 2000 mg daily divided into 3 to 4 doses for 7 to 10 days. The total daily dose should not exceed 2g.

Children's dosage

Pediatrics: Administer 10 mg (activity) per kg of body weight intravenously every 6 hours. Infants: Administer 10 to 15 mg (activity) per kg of body weight intravenously every 12 hours. For infants and newborns: One-time dose

This medication should not be used in patients with a history of severe allergic reactions or shock due to this drug. Patients who have had allergic reactions to this drug or to peptide-based or aminoglycoside antibiotics should also not receive it. Patients with hearing loss or those who have experienced hearing damage related to prior medications should use this drug cautiously. Patients with poor kidney function may have accumulation of this drug, so blood levels should be closely monitored. Patients with impaired liver function should also be careful as this drug may worsen liver function. The elderly, premature infants, and newborns may have weak kidney function and should be given this drug cautiously. This drug can affect the central nervous system; if any abnormal symptoms occur, administration should be stopped immediately and treated accordingly. Gastrointestinal symptoms such as diarrhea, nausea, and vomiting may rarely occur. There may be a decrease in blood cell counts, necessitating regular blood tests. Symptoms related to hearing such as hearing loss, dizziness, and tinnitus may occur, and hearing tests are recommended. Abnormal liver function test results may appear, so regular testing is needed. Kidney function may decline, requiring frequent blood tests to check kidney status. Severe rashes, blisters, and severe dermatitis may appear on the skin; it is important to report any abnormal symptoms immediately. Allergy symptoms such as rash, shortness of breath, and low blood pressure may occur, necessitating careful monitoring. If the infusion rate is too fast, rashes and pain as well as muscle spasms may appear on the face and body, so it should be administered slowly. Rare side effects such as fever, phlebitis, and pseudomembranous colitis have also been reported, so consult a doctor if any abnormal symptoms occur. This drug should only be used for the minimum duration needed to prevent the development of resistant bacteria, and patients with reduced kidney function require dose adjustments and monitoring. Long-term use may result in diarrhea and abdominal pain due to bacterial imbalance, and administration should be stopped if symptoms do not improve. Regular hearing tests are recommended to reduce the risk of auditory toxicity. It is important to conduct regular blood tests and tests for liver and kidney functions to detect any adverse reactions early. If severe skin reactions occur, administration of this drug should be stopped immediately. If diarrhea occurs after antibiotic use, consider the possibility of Clostridium difficile infection and consult a doctor. This drug may lead to severe allergic reactions when used with anesthetics, so pre-administering before anesthesia is beneficial. Co-administration with other neurotoxic or nephrotoxic drugs may worsen side effects, so careful monitoring is necessary. The risk of bleeding may increase when used with anticoagulants, requiring frequent checks on blood coagulation status. During pregnancy, safety for the fetus has not been fully established, so it should only be administered when absolutely necessary, and during breastfeeding, it is advisable to avoid use or to discontinue breastfeeding if possible. Pediatric patients, especially premature infants and newborns, have immature kidney function that may lead to elevated drug concentrations, so caution is warranted. The elderly may have reduced kidney function, so kidney function tests should be performed before and after administration, and doses adjusted if necessary. In cases of overdose, acute renal failure and hearing damage may occur, requiring appropriate treatment and supportive care. This drug must be administered intravenously; intramuscular injections or careless administration may cause tissue damage. The infusion rate should be slow, at least over 60 minutes, to reduce the risk of adverse reactions. Caution should be taken with mixed use of other drugs due to potential chemical instability.

Serious side effects

shock, anaphylactic symptoms, exfoliative dermatitis, bullous dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, rash, flushing, hypotension, wheezing, dyspnea, urticaria, drug hypersensitivity syndrome (DRESS, DIHS), red man syndrome, interstitial nephritis, jaundice, acute tubular necrosis, conductive hearing loss, renal failure, cardiac arrest, acute generalized exanthematous pustulosis (AGEP), linear IgA bullous dermatosis (LABD

Mild side effects

• loose stools
• diarrhea
• nausea
• vomiting
• abdominal pain
• anemia
• leukopenia
• thrombocytopenia
• eosinophilia
• dizziness

This medication must be stored in a sealed container to avoid exposure to air, and the storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius. Proper storage will preserve the drug's effectiveness for a longer period.

Appearance

This injection is a colorless, transparent vial containing a white to light yellowish brown lyophilized powder.

Package unit

10 vials/box [(1g activity/vial)]