Precifen Injection (Acetaminophen)

Adult administration

Adults weighing 50 kg or more 4 times a day, 1000 mg of acetaminophen per dose, with a minimum dosing interval of about 4 hours. The maximum daily dosage should not exceed 4 grams. Adults weighing 50 kg or more but under 33 kg can take approximately 15 mg/kg of acetaminophen per administration, with a minimum dosing interval of 4 hours. The maximum daily dosage should not exceed 60 mg/kg or 4 grams.

Child administration

Children weighing 33 kg (about 11 years) or older For each administration, approximately 15 mg/kg of acetaminophen, with a minimum dosing interval of 4 hours. The maximum daily dosage should not exceed 60 mg/kg or 4 grams.

Care should be taken not to confuse the units of medication dosage, milligrams and milliliters, when administering this drug. Incorrect administration can lead to sudden toxicity or serious side effects, which can be fatal. As soon as oral medication can be administered, it is advisable to switch to an appropriate analgesic as soon as possible. When taking this medication, always check whether acetaminophen is included in other medications already being taken. This is to avoid overdose. Exceeding the recommended dosage can cause serious liver damage, so strict adherence to the dosage is essential. Symptoms of liver damage can usually appear between 2 days to 6 days after administration, so careful observation is required. Patients with impaired liver function should strictly consult a doctor before administration, and those using high doses for a long time should regularly undergo liver function tests. People who consume large amounts of alcohol daily should consult their doctor or pharmacist before taking this medication, as combining it with alcohol increases the risk of liver damage. Rarely, severe rashes, hives, blisters, or serious allergic reactions on the skin may occur, and if such symptoms appear, administration should be immediately stopped and medical personnel should be informed. This medication should not be administered to patients who are hypersensitive to acetaminophen or this drug, or who have specific diseases, such as severe liver, kidney, heart diseases, blood disorders, peptic ulcer patients, or patients with a history of aspirin-induced asthma. Patients with liver or kidney disease, elderly patients, children, pregnant or breastfeeding women, and patients taking certain medications should be especially cautious and should consult a doctor before using this medication. Rarely, side effects such as malaise, hypotension, increased liver enzyme levels, blood cell counts decrease, renal failure, skin rashes may occur after administration, so if any abnormal symptoms arise, please inform medical personnel immediately. This medication can interact with certain drugs, so if you are currently taking any medications, be sure to inform your healthcare provider, as some medications may require dosage adjustment or caution when taken together. When receiving this medication, there is no hindrance to driving or operating machinery, and it should not be mixed with other medications. Children and the elderly should use the minimum dosage and pay special attention to adverse reactions, as there may be a rapid drop in body temperature or symptoms of collapse and peripheral cooling, necessitating observation. The use of this medication during pregnancy is limited, and it should be used only after careful assessment of benefits and risks. Breastfeeding women can use this drug as well, as although a small amount is excreted in breast milk, no adverse reactions have been reported. Patients with severely impaired kidney function should allow a minimum interval of more than 6 hours between doses due to slow excretion. In case of overdose, symptoms such as nausea, vomiting, loss of appetite, and abdominal pain may appear within 24 hours, and in severe cases, it can lead to hepatocellular damage and brain damage, hence immediate hospital visit for detoxification treatment is required. This medication should not be stored at temperatures above 30 degrees Celsius, and refrigeration or freezing should be avoided, and before use, check for foreign substances or discoloration, and dispose of any remaining medication after single use.

Serious side effects

Hives, severe swelling (edema), anaphylactic shock, shock, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, thrombocytopenia, agranulocytosis, neutropenia, leukopenia, liver failure, fulminant hepatitis, liver necrosis, angioedema, anaphylaxis, coma, acute renal failure, Lyell's syndrome.

Mild side effects

• Malaise
• hypotension
• increased levels of liver transaminases
• neurological disorders
• spotted rash
• injection site reactions
• papular rash
• pemphigus-like reactions
• pustular rash
• nausea

This medication should be stored at room temperature between 1 and 30 degrees Celsius, and it is important to store it in a sealed container to avoid exposure to air. Proper storage will help maintain the effectiveness of the medication and prevent degradation.

Appearance

A clear pale yellow transparent liquid filled in a colorless transparent plastic container for injection.

Package unit

100 milliliters/box