Nexgplitin Tablet 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

The recommended dose for this medication is 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. Adjustment of dosage is necessary for patients with renal impairment as per renal function. In cases of mild to moderate renal impairment (glomerular filtration rate [eGFR] ≥ 45 mL/min/1.73 m2 and < 90 mL/min/1.73 m2), no dosage adjustment is needed.

This medication may cause serious allergic reactions during use; therefore, if symptoms such as severe rash or swelling, difficulty breathing, etc. occur, stop taking the medication immediately and consult a doctor. This medication may induce pancreatitis, which is inflammation of the pancreas, so quickly inform healthcare professionals if symptoms such as abdominal pain, vomiting, or nausea occur. This medication should not be administered to patients with type 1 diabetes or diabetic ketoacidosis, nor should it be used in people who are allergic to this medication or its components. For patients with reduced renal function, dosage adjustments are necessary, so regular kidney function tests should be conducted and taken according to the doctor's instructions. During the use of this medication, symptoms of hypoglycemia may occur, especially when taken with insulin or sulfonylureas; therefore, blood sugar levels should be closely monitored, and medication dosages should be adjusted as needed. If severe joint pain or skin blistering symptoms occur during treatment, immediately inform a doctor and discontinue medication. It is advisable for pregnant or breastfeeding women not to use this medication, and safety and efficacy in children or adolescents under 18 years of age have not been established. In cases of overdose, standard treatment should be taken, and blood dialysis may be utilized for partial removal as directed by healthcare professionals. No significant interactions have been reported when used with other diabetes medications or certain cardiovascular drugs; however, it is essential to consult a doctor or pharmacist when taking other medications. For elderly patients, kidney function may decline, so it is important to regularly assess kidney function before and during use and adjust dosages accordingly.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), high fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa (severe skin adverse reactions), acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis), shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever (respiratory issues), skin conditions

Mild side effects

• Upper respiratory infections
• nasopharyngitis
• headache
• diarrhea
• nausea
• constipation
• muscle pain
• limb pain
• back pain
• pruritus

This medication should be stored in a sealed container that prevents air from entering and should be kept at room temperature between 1 and 30 degrees Celsius to maintain its efficacy and safety.

Appearance

Pink, round, biconvex, film-coated tablet

Package unit

30 tablets - 10 tablets/PTP [x3]