Clarithride Tablets (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) twice daily. In this case, it must be given in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: For 14 days, administer this medicine 500mg (potency) three times daily in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years or older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

This medicine should not be used in certain patients. For example, it may be risky for patients allergic to its ingredients or similar antibiotics, those with heart rhythm problems or a history of heart disease, and patients with severe liver or kidney dysfunction. Additionally, women who are pregnant or nursing are advised not to take this medicine. Serious side effects can occur when taken with certain medications, so those on other medications should consult their doctor or pharmacist. While taking this medicine, side effects such as allergic reactions, skin rashes, indigestion, diarrhea, dizziness, changes in hearing may occur, so if symptoms are severe or persist, medical attention should be sought immediately. In particular, if abnormal heartbeats, severe allergic reactions, or severe diarrhea occur, the medication should be stopped immediately, and a doctor should be consulted. This medicine may affect liver and kidney function, so patients with liver or kidney problems need regular monitoring, and dosage adjustments may be necessary. Moreover, this medicine has a high potential for interaction with other drugs, so caution is required when co-administered, and specific guidelines should be followed when taken with certain cardiac medications, anticoagulants, antidiabetic drugs, and sedatives. Lastly, prolonged or repeated use of this medicine may lead to antibiotic resistance, so it should only be taken for the prescribed duration according to the doctor’s instructions.

Shock, anaphylactic symptoms, dyspnea, convulsions, flush, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, indigestion, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, tremor, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, increased LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, myalgia, weakness, elevated CPK, increased myoglobin, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, gustatory disturbance, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis (AGEP), vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, rash, diaphoresis, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal stiffness, myopathy, elevated blood urea, injection site venous thrombosis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medicine should be stored in a cool, dry place away from direct sunlight and at room temperature between 1°C and 30°C. It is also essential to store it in a tightly sealed container to prevent air from entering.

Appearance

Yellow oval film-coated tablets

Package unit

Bottle packaging - 30 tablets/bottle, Bottle packaging - 100 tablets/bottle