Nexaron Tablet 20 mg (Escitalopram Oxalate)

Adult administration

This medication is administered once daily in the morning or evening, with or without food. 1) Adults (1) Major depressive disorder: The usual dose is 10mg once daily. The dose may be increased to a maximum of 20mg per day according to the patient’s response. When increasing the dose to 20mg, allow an interval of at least 1 week. (2) Panic disorder, with or without agoraphobia: The initial dose is 5mg per day for 1 week, followed by an increase to 10mg per day. The dose may be increased to a maximum of 20mg per day according to the patient’s response. (3) Social anxiety disorder: The usual dose is 10mg once daily. Improvement in symptoms may take 2-4 weeks; thereafter, depending on the patient’s response, the dose may be reduced to 5mg per day or increased to a maximum of 20mg per day. (4) Generalized anxiety disorder: The initial dose is 10mg once daily. After at least 1 week of treatment, the dose may be increased to a maximum of 20mg per day according to the patient’s response. (5) Obsessive-compulsive disorder: The usual dose is 10mg once daily. The dose may be increased to a maximum of 20mg per day according to the patient’s response. 2) Patients with renal impairment: No dose adjustment is necessary in patients with mild or moderate renal impairment. Caution is required in patients with severe renal impairment (CLCR < 30㎖/min). 3) Patients with hepatic impairment: An initial dose of 5mg per day for the first 2 weeks is recommended. The dose may be increased to 10mg per day according to the patient’s response. 4) When discontinuing treatment, the dose should be gradually reduced over at least 1-2 weeks.

This medication is an antidepressant used for the treatment of psychiatric disorders such as major depression. Care should be taken as this medication may increase the risk of suicidal thoughts or suicidal behavior in children, adolescents, and young adults aged 18 to 24. All patients taking this medication should be closely monitored for abnormal behavior changes such as suicidal tendencies, worsening depression, and aggression, particularly at the beginning of treatment and during dosage changes. It is also important for family members or guardians to closely observe the patient's condition and to guide them to consult a physician immediately if abnormal signs occur. This medication should not be taken with certain other medications, especially monoamine oxidase inhibitors (MAOIs), pimodivir, or drugs that prolong the QT interval, as serious side effects may occur. Patients with closed-angle glaucoma or a history of glaucoma should use this medication with caution because pupil dilation may raise intraocular pressure. Side effects such as anxiety, insomnia, dizziness, changes in appetite, and gastrointestinal disturbances may occur during the initial 1-2 weeks of taking this medication, but most will decrease over time. In particular, this medication may cause heart rhythm disturbances, so patients with heart disease or a long QT interval may require an electrocardiogram prior to and during treatment. Additionally, abrupt discontinuation of this medication may lead to withdrawal symptoms such as dizziness, anxiety, and sleep disturbances; therefore, dosage should be gradually reduced under a physician's guidance. Pregnant or breastfeeding women should consult a physician as the use of this medication may affect the newborn. The elderly should start with a lower dosage and adjust the dosage carefully, and they may need to be cautious when driving or operating machinery. Overdose of this medication may lead to severe symptoms affecting the central nervous system, cardiovascular system, and gastrointestinal system, so immediate medical attention is required. The safety and efficacy of this medication in children and adolescents have not been established, and its use is not recommended.

Thrombocytopenia, anaphylactic reaction, inappropriate secretion of antidiuretic hormone, hyperprolactinemia, decreased appetite, increased appetite, weight gain, weight loss, hyponatremia, anorexia, anxiety, restlessness, abnormal dreams, decreased libido, sexual dysfunction, bruxism, agitation, neuroticism, panic attack, confusion, aggression, depersonalization, hallucination, mania, suicidal thoughts, suicidal behavior, insomnia, drowsiness, dizziness, paresthesia, tremor, dysgeusia, sleep disorder, fainting, serotonin syndrome, movement disorders, motor dysfunction, convulsions, psychomotor agitation, akathisia, mydriasis, visual impairment, tinnitus, tachycardia, bradycardia, QT interval prolongation on electrocardiogram, polymorphic ventricular tachycardia, ventricular arrhythmia, orthostatic hypotension, sinusitis, yawning, nosebleed, nausea, diarrhea, constipation, vomiting, thirst, gastrointestinal bleeding, hepatitis, abnormal liver function test, increased sweating, urticaria, hair loss, rash, itching, petechiae, angioedema, arthralgia, myalgia, rhabdomyolysis, urinary retention, ejaculatory dysfunction, erectile dysfunction, uterine bleeding, menorrhagia, galactorrhea, postpartum hemorrhage, priapism, fatigue, fever, edema, headache, xerostomia, abdominal pain, dyspepsia, enteritis, sensory abnormalities, cough, asthma, dyspnea, fractures, palpitations, hypertension, paralysis, extrapyramidal symptoms, migraine, hallucination, asthma, dyspnea, fractures, arthralgia, hypertension, xerostomia, tremor, weight gain, abdominal discomfort, anxiety, insomnia, visual hallucinations, increased urination, sedation, heartburn, thirst, decreased libido, decreased appetite, drowsiness, gastrointestinal disorder

This medication may be sensitive to light, so it should be stored in a container that prevents light exposure. Additionally, it is best to store the medication at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's effectiveness over time.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle