Heureons Injection 150 IU/mL (Sodium Heparin)

Adult dosage

The method of use during extracorporeal circulation (blood dialysis) is as follows: 1. Systemic heparinization: administer 1,000 to 5,000 units before starting dialysis. 2. After starting dialysis: administer continuously 500 to 1,500 units per hour, or intermittently add 500 to 1,500 units every hour. 3. Regional heparinization: administer continuously 1,500 to 2,500 units per hour. 4. Intravascular perfusion use protamine.

This medication is very potent and should only be used under the strict supervision of a physician. Extra caution should be exercised when used in patients with diseases that pose a high risk of bleeding, as various bleeding can occur in patients who have received this medication. It should not be administered to patients who are allergic to this medication, have inappropriate blood coagulation test results, are bleeding, or have severe liver or kidney disease. Additionally, patients who have had recent central nervous system or eye surgeries, those who have received spinal or epidural anesthesia, and those with a history of severe thrombocytopenia due to this medication should also be excluded from receiving it. Patients with consumptive coagulopathy, those with catheters inserted, pregnant women in late pregnancy, patients with impaired liver or kidney function, children, and the elderly should use this medication with caution and frequently check their blood coagulation status. This medication can cause a variety of side effects such as bleeding, thrombocytopenia, liver dysfunction, allergic reactions, skin abnormalities, etc., so if any unusual symptoms occur during administration, the physician should be notified immediately. Blood coagulation test results should be frequently monitored, and if there are signs of bleeding, the administration should be stopped or adjusted; stopping it suddenly may lead to a risk of thrombosis, so the dosage should be decreased gradually. If the anticoagulant effect of this medication needs to be rapidly reversed, protamine sulfate, an antidote, should be used. If there is a rapid decrease in platelet count, administration should be stopped immediately, and further tests should be conducted, as immunological thrombocytopenia caused by this medication may still occur after stopping administration. This medication can interact with various drugs, so if you are taking other medications, you must inform your doctor or pharmacist. Women who are pregnant or may become pregnant should exercise special caution during administration due to the risk of bleeding in the uterus and placenta while breastfeeding; however, this medication is safe as it does not pass into breast milk. In case of overdose, the risk of bleeding becomes very high, so one must go to the hospital immediately to receive an antidote, as side effects may occur during this process. When using this medication, thorough cleanliness of the injection site is required for infection prevention, and intramuscular injections should be avoided due to the risk of bleeding. Opened medications should be used immediately, and any remaining medication should be discarded; mixed injections with other medications should be avoided.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, dyspnea, shock, angioedema, vasospastic reaction, heparin-induced thrombocytopenia, thrombocytopenia, bleeding (suspected gastrointestinal bleeding, intracranial hemorrhage, adrenal hemorrhage, ovarian hemorrhage, retroperitoneal bleeding, intracranial hemorrhage), severe edema accompanied by increased blood pressure, jaundice,

Mild side effects

• Itching
• chills
• fever
• rhinitis
• tearing
• conjunctivitis
• tachycardia
• feeling of pressure
• nausea
• vomiting

This medication should be stored in a sealed container to prevent air from entering, and it is important to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Storing it this way will help maintain the medication's effectiveness for a long time.

Appearance

A transparent solution that is colorless to light yellow, in a plastic container for injection.

Package unit

20 milliliters/ampoule[* 50]