Letracin Tablet 250mg (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years and older: Same as adults For children under 12 years, use clarithromycin dry syrup.

This drug should not be administered to patients with hypersensitivity to specific components. Special caution is necessary for individuals allergic to antibiotics in the same class as this drug. Additionally, it is not safe to use this drug in patients with severe heart diseases or impaired liver and kidney function. Pregnant or nursing women should also avoid taking this medication. This drug may interact with various other medications, so if you are currently taking any other medications, it is essential to inform your doctor or pharmacist. During treatment, if any abnormal symptoms such as allergic reactions, cardiac issues, gastrointestinal problems, or skin rashes occur, take the medication immediately and consult a healthcare professional. Although rare, severe skin diseases or cardiac arrhythmias may occur requiring prompt treatment upon symptom emergence. This drug can affect liver and kidney function, requiring regular testing and monitoring. Caution must be exercised when prescribing to children, the elderly, and immunocompromised patients, and dosage adjustments may be necessary. If gastrointestinal symptoms persist, such as diarrhea or abdominal pain, consult a specialist. Overdosage may cause gastrointestinal disturbances or psychiatric symptoms, so prescribed dosages must be strictly adhered to. This drug is generally stored at room temperature and should not be refrigerated.

Shock, anaphylactic symptoms, shortness of breath, convulsions, redness, rash, itching, hives, skin redness, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, taste loss, smell loss, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, hepatic dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, myalgia, weakness, increased CPK, elevated myoglobin, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute generalized exanthematous pustulosis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic-like reaction, angioedema, anorexia, decreased appetite, hypoglycemia, insomnia, anxiety, neurosensitivity, noise sensitivity, psychotic disorder, confusion state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, taste disturbance, headache, loss of consciousness, movement disorder, non-vestibular dizziness, drowsiness, tremors, convulsions, taste loss, abnormal olfaction, smell loss, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, premature contractions, palpitations, vasodilation, asthma, nasal bleeding, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal bloating, constipation, thirst, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, itching, hives, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal stiffness, myalgia, rhabdomyolysis, myopathy, elevated serum creatinine, elevated blood urea nitrogen, renal failure, nephritis, injection site thrombophlebitis, injection site pain, injection site inflammation, fatigue, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This drug is sensitive to light and should be stored in a tightly closed container that protects it from light. It is important to store it at room temperature between 15°C and 30°C to maintain its efficacy.

Appearance

Yellow oval film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 200 tablets/bottle