Retrocin 500 mg (Clarithromycin)

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years and older: Same as adults For children under 12 years, use clarithromycin dry syrup.

This medicine should not be used in patients who have allergies to certain ingredients or have had hypersensitivity reactions to certain antibiotics. Also, patients with cardiac conditions or severely impaired liver or kidney function should exercise caution when taking this medication. It is safer for pregnant or breastfeeding women to avoid using this medication. This medicine can interact with various other medications, so it is essential to inform the doctor or pharmacist of any currently taken medications. Rarely, serious allergic reactions or abnormal liver function, impaired kidney function, or heart arrhythmias may occur, so if any unusual symptoms arise, immediate consultation with healthcare professionals is necessary. Long-term or high-dose use may result in hearing loss, tinnitus, or muscle pain, so caution is advised. If gastrointestinal symptoms such as diarrhea or abdominal pain worsen during use, discontinue the drug and inform medical staff. Dosing may need to be adjusted based on body function when administering this medicine to children or the elderly. Caution is advised as dizziness or confusion may occur while driving or operating machinery. Overdosing may lead to gastrointestinal disturbances or psychiatric symptoms, so the prescribed dosage and regimen must be strictly adhered to.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, mild skin erythema, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormality, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, elevated liver enzymes, impaired liver function, hepatic failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, loss of appetite, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, elevated myoglobin in blood and urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disorder, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorders, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute generalized exanthematous pustulosis, soft tissue infection, candidiasis, gastroenteritis, infections, vaginal infections, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic-like reaction, hypersensitive anaphylactic reaction, angioedema, loss of appetite, reduced appetite, hypoglycemia, insomnia, anxiety, neurogenic irritability, auditory hallucinations, psychotic disorders, confused state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, taste disturbance, headache, loss of consciousness, movement disorder, non-vestibular dizziness, drowsiness, tremor, convulsions, loss of taste, abnormal olfaction, loss of smell, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, vasodilation, asthma, nosebleed, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal bloating, constipation, thirst, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, biliary stasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, hepatic failure, hepatocellular jaundice, rash, sweating, vesicular dermatitis, itching, urticaria, papular rash, acne, Henoch-Schönlein purpura, muscle cramps, musculoskeletal rigidity, myalgia, rhabdomyolysis, myopathy, elevated serum creatinine, elevated blood urea nitrogen, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, malaise, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medicine is sensitive to light, so it should be stored in a tightly sealed container that blocks light. It is essential to maintain a storage temperature between 15 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 200 tablets/bottle