Neurofem Injection 1 Gram (Meropenem Hydrate)

Adult administration

As Meropenem Hydrate, administer 0.5 to 1 g per day (potency), divided into 2 to 3 infusions over at least 30 minutes. For suspected infections in patients with bacterial pneumonia, peritonitis, or neutropenia, administer 1 g (potency) every 8 hours via slow intravenous infusion. For cystic fibrosis and meningitis, administer 2 g (potency) every 8 hours via slow intravenous infusion.

Child administration

For bacterial meningitis in children aged 3 months and older, administer 40 mg per kg of body weight via slow intravenous infusion over at least 30 minutes every 8 hours, according to the pathogen's sensitivity and the patient's condition.

This medication should not be administered to patients who have experienced shock from this medication in the past. Patients taking sodium valproate should be cautious as this medication may lower the blood concentration of valproate, potentially leading to the recurrence of seizures. Administration should be avoided in patients who have had allergic reactions to this medication or its components, or who have exhibited severe allergic reactions to other carbapenem or beta-lactam antibiotics. Caution is advised in users with a history of allergies, including asthma, rashes, or other allergic manifestations. Patients with impaired renal function may have the medication remain in the body longer, potentially causing central nervous system symptoms (seizures, altered consciousness), so dosage may need to be reduced or intervals increased. Patients with epilepsy or central nervous system disorders should also be cautious as seizures or altered consciousness may occur with this medication. Severely impaired liver function, elderly patients, those with poor nutritional status, or who receive parenteral nutrition, and infants under 3 months require special caution. This medication may rarely cause severe allergic reactions such as shock or anaphylaxis; therefore, patient status should be closely monitored during administration. If hypersensitivity reaction symptoms such as rashes, urticaria, itching, fever, erythema, flushing, vascular swelling, abdominal pain, diarrhea, nausea, vomiting, loss of appetite, oral candidiasis, flatulence, intestinal obstruction, indigestion, insomnia, anxiety, hallucination, confusion, dizziness, nervousness, paresthesia, hallucination, drowsiness, restlessness, depression, weakness, inflammation at the injection site, phlebitis, thrombophlebitis, or pain at the injection site occur, administration should be stopped immediately and appropriate treatment provided. Blood tests may reveal bone marrow-related side effects such as leukopenia, anemia, or thrombocytopenia, requiring regular monitoring, and if abnormalities are detected, administration should be stopped. Liver function abnormalities, acute hepatitis, jaundice, etc. may occur, necessitating regular liver function tests, and if abnormalities arise, administration should stop. Renal function may be compromised; therefore, routine kidney function tests should be conducted, and if abnormalities occur, administration should cease. Severe gastrointestinal adverse effects such as diarrhea or abdominal pain may occur, and should medication be symptomatic, it should be stopped immediately. Central nervous system side effects such as seizures and altered consciousness may arise, particularly in patients with renal or CNS diseases. Respiratory symptoms (asthma, dyspnea, etc.) if they arise, should lead to immediate cessation of administration and appropriate treatment. Severe skin reactions (Stevens-Johnson syndrome, Lyell syndrome, etc.) may rarely occur, so skin condition must be observed closely. Dysbiosis such as stomatitis and candidiasis may develop. There may be bleeding tendencies due to vitamin K deficiency; thus, care should be taken with bleeding symptoms. Cardiovascular adverse effects such as heart failure, arrhythmia, and abnormal blood pressure have been reported, so patients with heart disease should be cautious. Neuropsychiatric side effects can manifest as insomnia, agitation, and hallucinations, necessitating consultation with healthcare professionals regarding any unusual symptoms. Injection site reactions such as inflammation, pain, and swelling may occur. This medication has numerous drug interactions; thus, particular caution is needed when used with probenecid, valproate, anticonvulsants, contraceptives, and warfarin. Pregnant women should only use this medication if the therapeutic benefits outweigh potential risks, as safety has not been established. Breastfeeding women are advised to avoid this medication as it may be excreted in breast milk. Use in infants less than 3 months is discouraged due to the lack of established safety and efficacy. Elderly patients, with decreased bodily function, have a higher risk of side effects; therefore, dosage and administration intervals should be carefully adjusted. This medication is for intravenous use only and should be used promptly after reconstitution. When using this medication, sensitivity to the infectious agent should be confirmed, and it should be administered for only the minimum necessary duration to prevent the development of resistant strains. During administration, the patient's condition must be closely monitored, and appropriate measures should be taken immediately upon the emergence of any adverse reactions.

Serious side effects

Shock, anaphylaxis, urticaria, angioedema, rashes, toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome, DRESS syndrome, erythema multiforme, acute generalized exanthematous pustulosis (AGEP), pancytopenia, agranulocytosis, hemolytic anemia, hypochromic anemia, leukopenia, neutropenia, thrombocytopenia, decrease in hemoglobin, fulminant hepatitis, hepatic failure, jaundice.

Mild side effects

• Oral discomfort
• wheezing
• dizziness
• stools changes
• tinnitus
• sweating
• feeling of warmth
• erythema
• itching
• fever

This medication should be stored in a sealed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the efficacy and safety of the medication.

Appearance

A colorless transparent vial filled with white to light yellow crystalline powder.

Package unit

10 vials/box