Clarithromycin 500 mg Tablet

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) per dose, administered twice daily. For severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer for more than 14 days in these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days together with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1–14), and omeprazole 40mg once daily for 28 days (days 1–28).

Children's dosage

Children 12 years of age and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be administered to patients who are allergic to certain ingredients. In particular, those who have had hypersensitivity reactions to antibiotics of a similar class should avoid its use. Additionally, patients taking certain heart-related medications may face risks of cardiac arrhythmias, so co-administration should be avoided. Patients with severe heart disease or significantly impaired liver or kidney function should discuss with their doctor before using this medication. It is also safe for pregnant or breastfeeding women to avoid taking this medication. As this medication interacts with various drugs, it is important to inform healthcare providers if other medications are being taken. During treatment, adverse reactions such as allergic reactions, gastrointestinal disturbances, liver function abnormalities, kidney function decline, and skin rashes may occur, so monitoring should be done closely. If any adverse symptoms occur, discontinue the use of the medication and consult healthcare professionals immediately. Prolonged or high-dose administration may lead to auditory abnormalities or muscle-related side effects, so caution is needed. Elderly patients or those with impaired kidney function may require dose adjustments. Additionally, caution should be observed when driving or operating machinery. It is important to adhere to prescribed duration and dosage to prevent antibiotic resistance.

Shock, anaphylactic symptoms, shortness of breath, convulsions, redness, rash, itching, hives, skin erythema, angioedema, joint swelling, drug eruption, abdominal distention, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, changes in stool color, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug eruption associated with eosinophilia and systemic symptoms, jaundice, hepatocellular or cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, ageusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized pustular psoriasis, muscle cramps, musculoskeletal stiffness, myopathy, elevated serum creatinine, elevated blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light and should be stored in an opaque container. It should be kept at room temperature between 15 and 30 degrees Celsius, away from extreme heat or cold.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle