Anardemacapsule 1 mg (Anagrelide Hydrochloride)

Adult dose

In adults, the initial dose is 0.5mg 4 times daily or 1.0mg twice daily, administered under close observation and maintained for at least 1 week. In both adults and children, the dose should be the lowest effective dose needed to reduce the platelet count to 600,000/μL or below, while keeping the platelet count within the normal range as far as possible. If the dose is increased, the increment should be no more than 0.5mg/day, and the increased dose should not be increased further within 1 week. The maintenance dose does not differ between adult and pediatric patients. Do not exceed 2.5mg as a single dose or 10mg as the total daily dose. To monitor the effect of this medicine and prevent the onset of thrombocytopenia, measure the platelet count every 2 days during the first week of treatment and at least once weekly after the maintenance dose is reached. Generally, the platelet count begins to decrease within 7-14 days at the appropriate dose. When a complete response is defined as a platelet count of 600,000/μL or below, the time to achieve this is 4-12 weeks. Most patients will show an adequate response at doses of 1.5-3.0mg/day.

Child dose

The initial dose in children should range from 0.5mg/day to 0.5mg 4 times daily; based on limited data, an initial dose of 0.5mg/day is recommended for children.

This medication should not be used in patients with severely impaired liver function as its concentration in the body may increase significantly in those with moderate to severe liver damage. It contains lactose, so it should not be administered to patients with lactose intolerance or certain hereditary metabolic disorders. Patients with known or suspected heart disease should use this medication with extreme caution as it may increase heart rate and contractility, which can put a strain on the heart. All patients are recommended to undergo cardiovascular assessments such as echocardiograms or electrocardiograms before administration, and to closely monitor their heart condition during treatment. Patients with even slightly impaired liver function should also exercise caution when using this medication, and the benefits and risks of treatment should be carefully assessed through liver function tests. Interstitial lung diseases such as lung inflammation or pneumonia may rarely occur with this medication, so any symptoms such as difficulty breathing or cough should be reported to healthcare professionals immediately. Patients with pulmonary hypertension also require special caution when using this medication, and thorough evaluation of cardiopulmonary condition should be conducted before and during treatment. Long-term use of this medication can commonly lead to side effects such as headaches, palpitations, fluid retention, nausea, diarrhea, dizziness, depression, amnesia, confusion, insomnia, sensory disturbances, sensory loss, neurasthenia, dry mouth, migraines, stuttering, drowsiness, abnormal coordination, diplopia, vision abnormalities, tinnitus, elevated blood pressure, increased blood creatinine, weight loss, weight gain, joint pain, muscle pain, back pain, erectile dysfunction, nocturia, fatigue, chest pain, fever, chills, malaise, weakness, flu-like symptoms, and asthenia. Dose adjustment can minimize these side effects. During treatment, regular blood tests and monitoring of liver function, kidney function, and electrolyte levels are necessary, and any abnormal findings should be reported to healthcare providers immediately. Abruptly discontinuing this medication may lead to a rapid increase in platelet count, which can result in serious complications such as thrombosis, so discontinuation must be done according to physician's instructions. The risk of bleeding may be increased when taken with aspirin, so the risks and benefits of concomitant use should be carefully evaluated. Pregnant women or those who may become pregnant should not use this medication, and if pregnancy is confirmed during treatment, it should be discontinued immediately and healthcare professionals should be consulted. Breastfeeding women should also carefully consider the impact on their infant before using this medication, weighing the decision to breastfeed against medication use. It can be used in children and elderly patients, but elderly patients have a higher risk of cardiac-related side effects and should be monitored closely. In cases of overdose, decreased platelet counts and toxic responses in the cardiovascular and central nervous systems can occur, necessitating immediate medical management and monitoring of platelet counts. This medication should be kept out of reach of children, and transferring it to another container is not advisable as it can compromise quality.

Headache, palpitations, fluid retention, nausea, diarrhea, anemia, pancytopenia, thrombocytopenia, bleeding, petechiae, edema, weight loss, weight gain, dizziness, depression, forgetfulness, confusion, insomnia, sensory abnormalities, sensory loss, neurasthenia, dry mouth, migraine, stuttering, drowsiness, abnormal coordination, cerebral infarction, diplopia, vision abnormalities, tinnitus, tachycardia, ventricular tachycardia, congestive heart failure, atrial fibrillation, supraventricular tachycardia, arrhythmia, hypertension, syncope, myocardial infarction, cardiomyopathy, myocardial hypertrophy, pericardial effusion, angina pectoris, orthostatic hypotension, vasodilation, Prinzmetal angina, Torsades de Pointes, pulmonary hypertension, pneumonia, pleural effusion, dyspnea, nosebleed, pulmonary infiltrates, interstitial lung disease including pneumonia and allergic alveolitis, diarrhea, vomiting, abdominal pain, nausea, gastrointestinal air retention, gastrointestinal bleeding, pancreatitis, loss of appetite, dyspepsia, constipation, gastrointestinal diseases, colitis, gastritis, gum bleeding, elevated liver enzymes, hepatitis, rash, alopecia, pruritus, skin discoloration, dry skin, arthralgia, myalgia, low back pain, erectile dysfunction, renal failure, nocturia, tubulointerstitial nephritis, fatigue, chest pain, fever, chills, malaise, weakness, flu-like symptoms, asthenia, elevated blood creatinine, thrombosis, rectal bleeding, increased ALP, acute renal failure, leukopenia, generalized weakness, chest discomfort, pain in the right ear, visual impairment, photosensitivity dermatitis, increased white blood cell count, decreased exercise tolerance, loose stools, loss of appetite, sinus tachycardia

This medication should be stored in a tightly closed container to prevent exposure to air and light, kept away from direct sunlight, and maintained at a temperature between 1 and 30 degrees Celsius.

Appearance

Hard capsule with gray upper part and white lower part filled with white powder

Package unit

30 capsules/bottle, 100 capsules/bottle