Solafesin 10 mg (Solfenacin Succinate)

Adult dose

The usual recommended dose for adults, including older adults, is 5mg once daily. If needed, the dose may be increased to a maximum of 10mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. The dosage must be adjusted for the following patients. 1. Patients with renal impairment No dose adjustment is necessary in patients with mild to moderate renal impairment (creatinine clearance>30ml/min). Use with caution in patients with severe renal impairment (creatinine clearance≤30ml/min), and do not exceed 5mg once daily. 2. Patients with hepatic impairment No dose adjustment is necessary in patients with mild hepatic impairment. Use with caution in patients with moderate hepatic impairment (Child-Pugh class B), and do not exceed 5mg once daily. 3. Patients receiving potent cytochrome P450 3A4 (CYP3A4) inhibitors For patients receiving ketoconazole or another potent CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This drug is used to alleviate bladder hyperactivity. However, it should not be administered to certain patients. For example, patients with urinary retention symptoms, severe gastrointestinal diseases, severe myasthenia gravis, closed-angle glaucoma, allergies to this drug or its components, patients undergoing dialysis, and those with severe liver or kidney impairment should not be given this medication. Additionally, patients at risk of urinary retention or those with gastrointestinal obstructive disease, and some with severe renal impairment or moderate liver impairment should use this medication with caution and may need to limit the maximum dosage. Caution is also required when used in combination with strong CYP3A4 inhibitors. Common side effects of this medication include dry mouth and constipation, and may cause blurred vision or dry eyes. Rarely, urinary retention, angioedema, allergic reactions, and heart arrhythmias may occur, so it is essential to consult a healthcare professional if any unusual symptoms arise. This medication may require caution when driving or operating machinery due to drowsiness or blurred vision. Furthermore, when used in conjunction with other anticholinergic drugs, effects may be enhanced or side effects may worsen, necessitating careful monitoring. Pregnant or nursing women are advised to avoid this medication as its safety has not been established. It is also not recommended for children due to insufficient evidence of safety and efficacy. In case of overdose, central nervous system symptoms, blurred vision, or dizziness may occur, necessitating appropriate emergency care. Special caution should be taken for patients with a history of heart disease or those at risk of QT prolongation.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• nausea
• dyspepsia
• upper abdominal pain
• vomiting
• urinary tract infection

This medication should be stored in a tightly sealed container to protect it from exposure to air or moisture. It is best to store it at room temperature between 1 degree and 30 degrees Celsius, avoiding excessively hot or cold conditions.

Appearance

Round film-coated tablets in light pink color

Package unit

100 tablets/box [(10 tablets/PTP*10)]