Cimetidine Tablets (Cimetidine)

Adult dose

As cimetidine: 400 mg once, twice a day (morning, bedtime) orally, or 800 mg once a day (at bedtime). Alternately, 300 mg four times a day (after meals, at bedtime) can be administered. Dosage may be increased to 400 mg four times a day (after meals, at bedtime) (total 1.6 g) if necessary. To improve gastric mucosal lesions (erosions, bleeding, redness, swelling) of the following diseases: acute gastritis, acute exacerbation of chronic gastritis, administer 200 mg twice a day or 400 mg once a day. Also, for pain relief, antacids may be administered as needed. Dosage may be increased based on individual patient needs, but do not exceed the daily limit of 2.4 g. For renal impairment patients: administer 300 mg twice a day, every 12 hours. The frequency may be increased to three times a day, every 8 hours or more if necessary, with caution. Severe renal impairment patients may retain the medication in the body, so the frequency should be minimized based on the patient's response. Hemodialysis lowers blood cimetidine levels. After dialysis, resume medication as per the schedule. Adjust appropriately based on age and symptoms.

Child dose

Administer 20 to 40 mg divided per kg of body weight per day orally.

This medication should be handled very carefully during the use of glass ampoule injections, as glass fragments may contaminate the solution. Particularly, extra caution is needed when used in children and the elderly. It should not be administered to patients with hypersensitivity to this medication or those with a history of such reactions, and to patients taking dofetilide. Patients with impaired renal or liver function, patients with a history of drug hypersensitivity, elderly individuals, children under 19 years old, and patients on hemodialysis must take special care when using this medication, and dosage or intervals should be adjusted accordingly. Additionally, because symptoms of gastric cancer may be concealed, this medication should only be administered after confirming the malignancy, and patients with Helicobacter pylori infection should receive eradication therapy concurrently. Various side effects may occur, such as decreased blood cell counts, liver function abnormalities, renal dysfunction, hypersensitivity reactions, endocrine disorders, gastrointestinal symptoms, central nervous system disorders, cardiovascular issues, and skin reactions. Should any unusual symptoms arise, the treatment must be stopped immediately, and appropriate therapy should be initiated. If therapeutic effects are insufficient, alternative treatment methods should be considered, particularly monitoring blood, liver, and renal function periodically. Elderly patients, those with chronic diseases, and immunocompromised patients may have an increased risk of pneumonia and must be closely monitored. This medication may interact with several other drugs, so caution is needed when taken with coumarin anticoagulants, antidepressants, antiarrhythmics, and calcium channel blockers, requiring dosage adjustments and careful observation. Women who are pregnant or may become pregnant should use this medication only if the benefits outweigh the risks, and breastfeeding should be discontinued if this medication is necessary. Safety in pediatric patients has not been established, so careful administration is required. Elderly patients may have increased blood concentrations due to decreased kidney function, necessitating adjustments in dosage and administration intervals. In cases of overdose, respiratory depression may occur, and appropriate treatments such as artificial respiration and gastric lavage may be needed based on symptoms. When injecting intravenously, it is advisable to administer slowly in small amounts to reduce the risk of side effects. Keep out of reach of children, and avoid transferring to other containers.

Serious side effects

• Leukopenia
• agranulocytosis
• aplastic anemia
• thrombocytopenia
• pancytopenia
• aplastic anemia
• immune hemolytic anemia
• jaundice
• liver fibrosis
• interstitial seizures

Mild side effects

• General malaise
• weakness
• subcutaneous bleeding
• mucosal bleeding
• fever
• hepatitis
• elevated AST
• ALT
• abdominal distension
• constipation

This medication should be stored in a tightly sealed container to prevent air ingress, and storage temperatures should be maintained between 1°C and 30°C at room temperature. This way, the efficacy of the medication can safely be maintained.

Appearance

Light green round film-coated tablet

Package unit

Bottle - 500 tablets/bottle