Kvastin Tablet 5 mg (Rosuvastatin Calcium)

Adult dosage

The initial dose is 5 mg once daily, and if more LDL-cholesterol reduction is needed, it can be titrated to the maintenance dose. The maintenance dose is typically 10 mg once daily, and most patients are controlled at this dose. The maintenance dose should be adjusted appropriately based on LDL-cholesterol levels, treatment goals, and patient response at intervals of 4 weeks or more, with a maximum increase to 20 mg per day.

Children's dosage

The usual dosage range for pediatric patients with heterozygous familial hypercholesterolemia (ages 10-17) is 5 mg to 20 mg once daily. The administration dosage should be adjusted individually based on the recommended therapeutic goals for each patient.

This drug should not be used in certain patients. For example, it is contraindicated in patients who are allergic to this drug, have severely impaired liver function, have muscle disorders, have severe renal impairment, are pregnant or breastfeeding women, and in fertile women not using adequate contraception. Moreover, in patients at increased risk for muscle disorders, or when used in conjunction with certain medications, caution should be exercised in deciding the dosage or whether to administer this drug. For instance, patients with moderate to severe renal impairment, those with hypothyroidism, alcoholics, and those with a history of genetic muscle disorders or family history should be cautious. This drug contains lactose, so it should not be given to patients with genetic problems such as lactose intolerance. It is important to perform regular liver function tests and muscle-related tests while taking this drug. Specifically, patients with a history of liver disease or excessive alcohol consumption should regularly monitor liver enzyme levels. In case of symptoms such as myalgia, muscle weakness, or cramps, notify healthcare professionals immediately, and treatment with this drug can be discontinued if necessary. Furthermore, since muscle enzyme levels may increase due to exercise or other causes, caution is needed during testing. This drug can rarely cause severe skin reactions or liver damage, so if symptoms such as rash, fever, or jaundice occur, treatment should be stopped immediately, and healthcare professionals should be consulted. When used in conjunction with other medications, interactions may occur, so all medications being taken should be reported to healthcare professionals with caution. Especially, the risk of muscle injury may increase when combined with certain antiviral agents, immunosuppressants, and fibrate medications. Pregnant or breastfeeding individuals should not use this drug, and women who might become pregnant should use appropriate contraception. In cases of overdose, specific antidotes are not available, so treatment must follow the symptoms, and liver function and muscle enzyme tests are required. Caution is advised during driving or operation of machinery, as dizziness may occur. The drug's concentration may be higher in Asian individuals, so dosage adjustment may be necessary. Overall, this drug should be used with careful monitoring of liver and muscle health status, and it must be taken according to the physician's instructions.

Serious side effects

Hypersensitivity reactions including hives and angioedema, severe allergic reactions, rash, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), severe skin adverse reactions, pancreatitis, myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy, severe muscle weakness, ocular myasthenia, respiratory difficulties, breathing problems, jaundice, hepatitis, liver abnormalities, acute renal failure, oliguria, sudden and severe headache,

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• fatigue
• thrombocytopenia
• diarrhea

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is also recommended to store the medication at room temperature between 1°C and 30°C. This helps to maintain the effectiveness of the medication for a longer period.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle